Target Information

Target General Infomation
Target ID
T95302
Former ID
TTDI02123
Target Name
Melanocortin MC5 receptor
Gene Name
MC5R
Synonyms
MC2; Melanocortin receptor 5; MC5R
Target Type
Clinical Trial
Disease Acne vulgaris [ICD9: 706.1; ICD10: L70.0]
Seborrhea [ICD10: L21]
Function
Receptor for MSH (alpha, beta and gamma)and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
BioChemical Class
GPCR rhodopsin
UniProt ID
P33032
Sequence
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
Drugs and Mode of Action
Drug(s) JNJ-10229570 Drug Info Phase 2 Acne vulgaris [523417]
MTC-896 Drug Info Phase 2 Seborrhea [525128]
Antagonist JNJ-10229570 Drug Info [531491]
MTC-896 Drug Info [550319]
Agonist MT-II Drug Info [535447]
Pathways
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523417ClinicalTrials.gov (NCT01326780) A Study of a New Drug Treatment for Acne. U.S. National Institutes of Health.
Ref 525128ClinicalTrials.gov (NCT02395549) A Study to Determine the Efficacy of Topically Applied MTC896 Gel in Subjects With Acne Vulgaris. U.S. National Institutes of Health.
Ref 531491A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32.
Ref 535447The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57.
Ref 550319Clinical pipeline report, company report or official report of Avarx.

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