Target Information
Target General Infomation | |||||
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Target ID |
T95558
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Former ID |
TTDS00531
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Target Name |
Diacylglycerol O-acyltransferase 2
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Gene Name |
DGAT2
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Synonyms |
Diglyceride acyltransferase 2; DGAT2
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Target Type |
Successful
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Disease | Dyslipidaemias [ICD9: 272; ICD10: E78] | ||||
Lipid disorder; Cardiovascular disease [ICD9: 272, 390-459; ICD10: E78, I00-I99] | |||||
Function |
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).
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BioChemical Class |
Acyltransferase
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UniProt ID | |||||
EC Number |
EC 2.3.1.76
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Sequence |
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT MYMEALVKLFDKHKTKFGLPETEVLEVN |
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Drugs and Mode of Action | |||||
Pathways | |||||
BioCyc Pathway | Triacylglycerol biosynthesis | ||||
KEGG Pathway | Glycerolipid metabolism | ||||
Metabolic pathways | |||||
Fat digestion and absorption | |||||
Reactome | Acyl chain remodeling of DAG and TAG | ||||
Triglyceride Biosynthesis | |||||
WikiPathways | Triacylglyceride Synthesis | ||||
Glycerophospholipid biosynthesis | |||||
Fatty acid, triacylglycerol, and ketone body metabolism | |||||
References |
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