Target Validation Information
Target ID T83875
Target Name Amine oxidase [flavin-containing] A
Target Type
Successful
Drug Potency against Target 2-Chloro-N-(3-morpholinopropyl)nicotinamide Drug Info IC50 = 9400 nM [530675]
IPRONIAZIDE Drug Info IC50 = 5000 nM [530675]
2-Bromo-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 8500 nM [530675]
(E)-5-(3-Fluorostyryl)isatin Drug Info Ki = 2200 nM [530056]
7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin Drug Info Ki = 11000 nM [529080]
7-Bromo-4,9-dihydro-3H-beta-carboline Drug Info Ki = 400 nM [526993]
2-Furan-2-yl-4,5-dihydro-1H-imidazole Drug Info Ki = 2340 nM [526918]
PIPERINE Drug Info Ki = 19000 nM [530562]
(E)-5-Styrylisatin Drug Info Ki = 780 nM [530056]
Cis-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine Drug Info IC50 = 18000 nM [529607]
(E)-5-(3-Chlorostyryl)isatin Drug Info Ki = 5600 nM [530056]
8-[(3-Trifluoromethyl)benzyloxy]caffeine Drug Info Ki = 51 nM [530647]
C-(1H-Indol-3-yl)-methylamine Drug Info Ki = 3440 nM [526993]
8-(3-Fluorobenzyloxy)caffeine Drug Info Ki = 180 nM [530647]
Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate Drug Info Ki = 12840 nM [529853]
3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide Drug Info Ki = 2580 nM [531067]
(6-methylthio-2-naphthyl)isopropylamine Drug Info Ki = 500 nM [529986]
(R,S)-N-(R-phenylethyl)-1H-pyrrole-2-carboxamide Drug Info Ki = 1220 nM [528641]
N-(4-Phenylbutyl)-1H-indole-2-carboxamide Drug Info Ki = 2200 nM [529768]
7-Methoxy-9H-beta-carboline Drug Info Ki = 87 nM [526993]
(6-Ethoxy-2-naphthyl)-2-aminopropane Drug Info Ki = 450 nM [529986]
(+/-)-2-(4'-Methoxyphenyl)thiomorpholine Drug Info Ki = 6390 nM [530683]
6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 2785 nM [526993]
(+/-)-2-(4'-Propoxyphenyl)thiomorpholine Drug Info Ki = 3690 nM [530683]
7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 1290 nM [526993]
4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid Drug Info IC50 = 9970 nM [530001]
N-phenyl-1H-pyrrole-2-carboxamide Drug Info Ki = 400 nM [528641]
8-(3-Bromobenzyloxy)caffeine Drug Info Ki = 23 nM [530647]
2-oxo-N-phenyl-2H-chromene-3-carboxamide Drug Info IC50 = 13120 nM [530001]
Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine Drug Info IC50 = 3600 nM [529607]
N-Benzyl,N-methyl-1H-indole-2-carboxamide Drug Info Ki = 70 nM [529768]
(S)-2-amino-1-(4-ethylthiophenyl)-propane Drug Info Ki = 54 nM [528855]
6-Chloro-N-(3-morpholinopropyl)nicotinamide Drug Info IC50 = 380 nM [530675]
4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one Drug Info IC50 = 40.5 nM [529735]
N-(1H-Indol-2-ylmethyl)-N-(4-phenylbutyl)amine Drug Info Ki = 10000 nM [529768]
2-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-imidazole Drug Info Ki = 13570 nM [529853]
5,6-Dichloro-N-(3-morpholinopropyl)nicotinamide Drug Info IC50 = 100 nM [530675]
(S)-2-amino-1-(4-butylthiophenyl)-propane Drug Info Ki = 392 nM [528855]
5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 300 nM [526993]
8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 270 nM [526993]
N-(propargyl),N-(pyrrol-2-ylmethyl)amine Drug Info Ki = 300 nM [528641]
3,4-Benzo-7-acetonyloxy-8-methoxycoumarin Drug Info IC50 = 11930 nM [529735]
2-oxo-N-m-tolyl-2H-chromene-3-carboxamide Drug Info IC50 = 14500 nM [530001]
5-Bromo-4,9-dihydro-3H-beta-carboline Drug Info Ki = 86 nM [526993]
6-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info Ki = 480 nM [526994]
N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide Drug Info IC50 = 12400 nM [529025]
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one Drug Info Ki = 12300 nM [530683]
5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 5.4 nM [526993]
(+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one Drug Info Ki = 9280 nM [530683]
6,11-dihydro-5H-benzo[a]carbazole Drug Info IC50 = 12000 nM [529077]
8-Bromo-4,9-dihydro-3H-beta-carboline Drug Info Ki = 17 nM [526993]
N-methyl-N-(prop-2-ynyl)-1H-pyrrole-2-carboxamide Drug Info Ki = 75 nM [528641]
(7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile Drug Info IC50 = 200 nM [530434]
3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin Drug Info IC50 = 2380 nM [529735]
N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide Drug Info Ki = 18290 nM [531067]
Ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate Drug Info IC50 = 15980 nM [530001]
N2-[4-(benzyloxy)benzyl]glycinamide Drug Info IC50 = 8500 nM [529025]
3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide Drug Info Ki = 8180 nM [531067]
2-phenyl-9H-indeno[2,1-d]pyrimidine Drug Info IC50 = 16700 nM [529077]
Trans-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine Drug Info IC50 = 10000 nM [529607]
N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide Drug Info IC50 = 15670 nM [530001]
N-benzyl-1H-pyrrole-2-carboxamide Drug Info Ki = 250 nM [528641]
(+/-)-2-(4'-Butoxyphenyl)thiomorpholine Drug Info Ki = 14100 nM [530683]
(+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one Drug Info Ki = 10000 nM [530683]
4-methyl-2H-benzofuro[3,2-g]chromen-2-one Drug Info IC50 = 7240 nM [528005]
3-aminoacetamido-4'-methylfuro[3,2-g]coumarin Drug Info IC50 = 12350 nM [528005]
3-methyl-2(1H)-thioxo-4(3H)-quinazolinone Drug Info IC50 = 3420 nM [529873]
6-Bromo-4,9-dihydro-3H-beta-carboline Drug Info Ki = 790 nM [526993]
TOLOXATONE Drug Info Ki = 1800 nM [528273]
PNU-22394 Drug Info Ki = 1030 nM [526993]
(6-Benzyloxy-2-naphthyl)-2-aminopropane Drug Info Ki = 3780 nM [529986]
Cis-2-phenylcyclopropylamine Drug Info IC50 = 11000 nM [529607]
3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine Drug Info IC50 = 1.3 nM [527928]
2-(3-benzylquinoxalin-2-ylamino)ethanol Drug Info IC50 = 3.7 nM [527928]
1-(3-benzyl-6,7-dichloroquinoxalin-2-yl)hydrazine Drug Info IC50 = 7.6 nM [527928]
2-phenyl-5H-indeno[1,2-d]pyrimidine Drug Info IC50 = 18000 nM [529077]
(S)-2-amino-1-(4-methylthiophenyl)-propane Drug Info Ki = 245 nM [528855]
N'-(2-phenylallyl)hydrazine hydrochloride Drug Info IC50 = 1300 nM [528105]
Tranylcypromine Drug Info IC50 = 20000 nM [527283]
5-Azidomethyl-3-pyrrol-1-yl-oxazolidin-2-one Drug Info Ki = 200 nM [526287]
2-BFi Drug Info Ki = 1.7 nM [525733]
Beta-methoxyamphetamine Drug Info Ki = 250 nM [529986]
2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole Drug Info Ki = 13890 nM [529853]
N-Benzyl-(6-butoxy-2-naphthyl)-2-aminopropane Drug Info Ki = 14500 nM [529986]
8-(3-Methoxybenzyloxy)caffeine Drug Info Ki = 340 nM [530647]
6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 1640 nM [526994]
7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 12 nM [526918]
N-(1-Methyl-1H-indol-2-ylmethyl)-N-phenylamine Drug Info Ki = 10 nM [529768]
3,4-Benzo-7-acetonyloxy-8-methylcoumarin Drug Info IC50 = 2560 nM [529735]
9-(3-aminopropoxy)-7H-furo[3,2-g]chromen-7-one Drug Info IC50 = 2510 nM [528005]
N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine Drug Info Ki = 10 nM [529768]
(R)-Indan-1-yl-methyl-prop-2-ynyl-amine Drug Info IC50 = 70 nM [526455]
2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole Drug Info IC50 = 14851 nM
HARMINE Drug Info Ki = 5 nM [530562]
2-Phenoxymethyl-4,5-dihydro-1H-imidazole Drug Info Ki = 5 nM [526918]
TRACIZOLINE Drug Info Ki = 2 nM [526918]
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole Drug Info Ki = 6.5 nM [526994]
5-Methoxymethyl-3-pyrrol-1-yl-oxazolidin-2-one Drug Info Ki = 4.9 nM [526287]
1-(4-butoxyphenyl)propan-2-amine Drug Info Ki = 320 nM [529986]
8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 3.6 nM [526993]
(6-Butoxy-2-naphthyl)-2-aminopropane Drug Info Ki = 1530 nM [529986]
8-Benzyloxycaffeine Drug Info Ki = 590 nM [530647]
8-(3-Methylbenzyloxy)caffeine Drug Info Ki = 180 nM [530647]
1-(4-ethoxyphenyl)propan-2-amine Drug Info Ki = 220 nM [529986]
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide Drug Info Ki = 700 nM [528641]
1-(1-Naphthyl)-2-aminopropane Drug Info Ki = 5630 nM [529986]
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide Drug Info Ki = 600 nM [528641]
1-(2-Naphthyl)-2-aminopropane Drug Info Ki = 420 nM [529986]
1-(4-(benzyloxy)phenyl)propan-2-amine Drug Info Ki = 3420 nM [529986]
5-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info Ki = 84 nM [526993]
2-Amino-1-(4-methylthiophenyl)propane Drug Info Ki = 250 nM [529986]
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine Drug Info Ki = 20 nM [528641]
N-((1H-indol-2-yl)methyl)(phenyl)methanamine Drug Info Ki = 2100 nM [529768]
(+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine Drug Info Ki = 19000 nM [530683]
N-Benzyl-(6-methoxy-2-naphthyl)-2-aminopropane Drug Info Ki = 6930 nM [529986]
TRYPTAMINE Drug Info Ki = 5400 nM [526993]
(6-Propoxy-2-naphthyl)-2-aminopropane Drug Info Ki = 680 nM [529986]
1-(3-(4-chlorobenzyl)quinoxalin-2-yl)hydrazine Drug Info IC50 = 2.1 nM [527928]
TRYPTOLINE Drug Info Ki = 9.4 nM [526918]
N-(benzyl),N-(pyrrol-2-ylmethyl)amine Drug Info Ki = 350 nM [528641]
8-(3-Chlorobenzyloxy)caffeine Drug Info Ki = 36 nM [530647]
7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin Drug Info IC50 = 235 nM [529735]
4,9-Dihydro-3H-beta-carboline Drug Info Ki = 7.3 nM [526994]
N-Methyl,N-phenyl-1H-indole-2-carboxamide Drug Info Ki = 3.5 nM [529768]
N-(1H-Indol-2-ylmethyl)-N-phenylamine Drug Info Ki = 10000 nM [529768]
2-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 2600 nM [530675]
N-(2-Phenylethyl)-1H-indole-2-carboxamide Drug Info Ki = 170 nM [529768]
7-acetonyloxy-3-acetylamino-8-methoxycoumarin Drug Info IC50 = 6430 nM [528005]
N-(3-Phenylpropyl)-1H-indole-2-carboxamide Drug Info Ki = 5 nM [529768]
N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine Drug Info Ki = 60 nM [529768]
(S)-2-amino-1-(4-propylthiophenyl)-propane Drug Info Ki = 115 nM [528855]
5,6-Dichloro-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 84 nM [530675]
N-propargyl-1H-pyrrole-2-carboxamide Drug Info Ki = 230 nM [528641]
(+/-)-2-Phenylthiomorpholin-5-one Drug Info Ki = 9190 nM [530683]
6-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 180 nM [530675]
4-Chloro-N-(3-morpholinopropyl)nicotinamide Drug Info IC50 = 7500 nM [530675]
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide Drug Info Ki = 55 nM [528641]
6-Fluoro-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 15000 nM [530675]
9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info Ki = 5.4 nM [526993]
(R/R)BEFLOXATONE Drug Info Ki = 2.5 nM [526287]
2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole Drug Info Ki = 4.7 nM [526993]
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholine Drug Info Ki = 2170 nM [530683]
8-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info Ki = 160 nM [526993]
N-Phenyl-1H-indole-2-carboxamide Drug Info Ki = 130 nM [529768]
N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine Drug Info Ki = 5.4 nM [528641]
7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin Drug Info IC50 = 3.78 nM [529735]
1-(4-propoxyphenyl)propan-2-amine Drug Info Ki = 130 nM [529986]
N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide Drug Info IC50 = 13600 nM [529025]
(+/-)-2-Phenylthiomorpholine Drug Info Ki = 10600 nM [530683]
(+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one Drug Info Ki = 8680 nM [530683]
N-Phenyl-1-methyl-1H-indole-2-carboxamide Drug Info Ki = 10000 nM [529768]
N-Benzyl-1H-indole-2-carboxamide Drug Info Ki = 30 nM [529768]
N-((1H-indol-2-yl)methyl)-2-phenylethanamine Drug Info Ki = 1600 nM [529768]
(6-Methoxy-2-naphthyl)-2-aminopropane Drug Info Ki = 180 nM [529986]
4-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 750 nM [530675]
2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide Drug Info IC50 = 8000 nM [530434]
CGS-19281A Drug Info Ki = 18 nM [526994]
Trans-2-fluoro-2-p-tolylcyclopropanamine Drug Info IC50 = 13000 nM [529607]
2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole Drug Info Ki = 15750 nM [529853]
6-Hydroxy-N-(2-morpholinoethyl)nicotinamide Drug Info IC50 = 430 nM [530675]
2-(4,5-dihydro-1H-imidazol-2-yl)quinoline Drug Info IC50 = 12700 nM [529853]
2-oxo-N-p-tolyl-2H-chromene-3-carboxamide Drug Info IC50 = 19450 nM [530001]
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine Drug Info Ki = 3500 nM [528641]
Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine Drug Info IC50 = 1600 nM [529607]
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine Drug Info Ki = 24 nM [528641]
1-(3-benzylquinoxalin-2-yl)hydrazine Drug Info IC50 = 8.8 nM [527928]
4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin Drug Info IC50 = 400 nM [529735]
2-Phenethyl-4,5-dihydro-1H-imidazole Drug Info Ki = 5 nM [526918]
N-2-phenylethyl-1H-pyrrole-2-carboxamide Drug Info Ki = 420 nM [528641]
Moclobemide Drug Info IC50 = 361380 nM [530841]
HYDRAZINECARBOXAMIDE Drug Info IC50 = 6700 nM [527283]
MOFEGILINE Drug Info Ki = 1100 nM [529842]
Trans-2-fluoro-2-phenylcyclopropylamin Drug Info IC50 = 12000 nM [529607]
2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole Drug Info IC50 = 7883 nM
4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one Drug Info IC50 = 4400 nM [530434]
6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one Drug Info IC50 = 12200 nM [529735]
References
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 530056Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. Epub 2009 Mar 14.Inhibition of monoamine oxidase by (E)-styrylisatin analogues.
Ref 529080J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4.Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 530562Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. Epub 2009 Nov 26.Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.
Ref 530056Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. Epub 2009 Mar 14.Inhibition of monoamine oxidase by (E)-styrylisatin analogues.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 530056Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. Epub 2009 Mar 14.Inhibition of monoamine oxidase by (E)-styrylisatin analogues.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 529853Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Ref 531067Eur J Med Chem. 2010 Oct;45(10):4458-66. Epub 2010 Jul 31.Inhibition of monoamine oxidase by indole and benzofuran derivatives.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 530001J Med Chem. 2009 Apr 9;52(7):1935-42.Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 530001J Med Chem. 2009 Apr 9;52(7):1935-42.Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 528855Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. Epub 2007 May 22.Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529853Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 528855Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. Epub 2007 May 22.Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 530001J Med Chem. 2009 Apr 9;52(7):1935-42.Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 526994Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Ref 529025J Med Chem. 2007 Oct 4;50(20):4909-16. Epub 2007 Sep 7.Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 529077J Med Chem. 2007 Nov 1;50(22):5364-71. Epub 2007 Oct 2.Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530434J Med Chem. 2009 Nov 12;52(21):6685-706.Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 531067Eur J Med Chem. 2010 Oct;45(10):4458-66. Epub 2010 Jul 31.Inhibition of monoamine oxidase by indole and benzofuran derivatives.
Ref 530001J Med Chem. 2009 Apr 9;52(7):1935-42.Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Ref 529025J Med Chem. 2007 Oct 4;50(20):4909-16. Epub 2007 Sep 7.Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.
Ref 531067Eur J Med Chem. 2010 Oct;45(10):4458-66. Epub 2010 Jul 31.Inhibition of monoamine oxidase by indole and benzofuran derivatives.
Ref 529077J Med Chem. 2007 Nov 1;50(22):5364-71. Epub 2007 Oct 2.Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 530001J Med Chem. 2009 Apr 9;52(7):1935-42.Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 528005J Med Chem. 2006 Feb 9;49(3):1149-56.A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.
Ref 528005J Med Chem. 2006 Feb 9;49(3):1149-56.A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.
Ref 529873Bioorg Med Chem. 2009 Jan 15;17(2):675-89. Epub 2008 Dec 3.New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 528273J Nat Prod. 2006 Jun;69(6):945-9.Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and computational study.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 527928Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. Epub 2005 Dec 13.Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
Ref 527928Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. Epub 2005 Dec 13.Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
Ref 527928Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. Epub 2005 Dec 13.Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
Ref 529077J Med Chem. 2007 Nov 1;50(22):5364-71. Epub 2007 Oct 2.Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.
Ref 528855Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. Epub 2007 May 22.Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.
Ref 528105J Med Chem. 2006 Apr 6;49(7):2166-73.Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity.
Ref 527283J Med Chem. 2004 Nov 18;47(24):5860-71.Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxidase.
Ref 526287J Med Chem. 2002 Mar 14;45(6):1180-3.3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
Ref 525733Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7.Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 529853Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 526994Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 528005J Med Chem. 2006 Feb 9;49(3):1149-56.A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 526455J Med Chem. 2002 Nov 21;45(24):5260-79.Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Ref 530562Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. Epub 2009 Nov 26.Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 526994Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Ref 526287J Med Chem. 2002 Mar 14;45(6):1180-3.3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 527928Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. Epub 2005 Dec 13.Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530647Bioorg Med Chem. 2010 Feb;18(3):1018-28. Epub 2010 Jan 6.Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 526994Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 528005J Med Chem. 2006 Feb 9;49(3):1149-56.A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 528855Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. Epub 2007 May 22.Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 526287J Med Chem. 2002 Mar 14;45(6):1180-3.3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 529025J Med Chem. 2007 Oct 4;50(20):4909-16. Epub 2007 Sep 7.Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 530683Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. Epub 2010 Jan 15.2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529768Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. Epub 2008 Oct 2.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Ref 529986Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 530434J Med Chem. 2009 Nov 12;52(21):6685-706.Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Ref 526994Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 529853Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Ref 530675Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
Ref 529853Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Ref 530001J Med Chem. 2009 Apr 9;52(7):1935-42.Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 527928Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. Epub 2005 Dec 13.Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 528641J Med Chem. 2007 Mar 8;50(5):922-31. Epub 2007 Jan 26.New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Ref 530841Bioorg Med Chem Lett. 2010 May 1;20(9):2709-12. Epub 2010 Mar 27.Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.
Ref 527283J Med Chem. 2004 Nov 18;47(24):5860-71.Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxidase.
Ref 529842J Med Chem. 2008 Dec 25;51(24):8019-26.Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.
Ref 529607Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. Epub 2008 Jun 28.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Ref 530434J Med Chem. 2009 Nov 12;52(21):6685-706.Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Ref 529735J Med Chem. 2008 Nov 13;51(21):6740-51. Epub 2008 Oct 4.Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.