Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T31479 | ||||
Target Name | Phospholipase A2 | ||||
Target Type | Successful |
||||
Drug Potency against Target | Petrosaspongiolide P | Drug Info | IC50 = 3800 nM | [534632] | |
BOLINAQUINONE | Drug Info | IC50 = 100 nM | [526069] | ||
4'-hydroxy-6,3',5'-triprenylisoflavonone | Drug Info | IC50 = 10000 nM | |||
Mepacrine | Drug Info | IC50 = 17 uM | |||
3,9-dihydroxy-2,10-diprenylpterocap-6a-ene | Drug Info | IC50 = 3000 nM | |||
ABYSSINONE V | Drug Info | IC50 = 6000 nM | |||
URSOLIC ACID | Drug Info | IC50 = 2300 nM | [527616] | ||
HELENAQUINONE | Drug Info | IC50 = 3700 nM | [531037] | ||
CACOSPONGIONOLIDE | Drug Info | IC50 = 2300 nM | [534672] | ||
MANOALIDE | Drug Info | IC50 = 400 nM | [528597] | ||
HYRTIOSULAWESINE | Drug Info | IC50 = 14000 nM | [528597] | ||
References | |||||
Ref 534632 | J Nat Prod. 1998 May;61(5):571-5.Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra. | ||||
Ref 526069 | J Nat Prod. 2001 May;64(5):612-5.New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions. | ||||
Ref 527616 | Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. | ||||
Ref 531037 | Bioorg Med Chem. 2010 Aug 15;18(16):6006-11. Epub 2010 Jun 25.New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. | ||||
Ref 534672 | J Nat Prod. 1998 Jul;61(7):931-5.A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides. | ||||
Ref 528597 | J Nat Prod. 2006 Dec;69(12):1676-9.Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus. | ||||
Ref 528597 | J Nat Prod. 2006 Dec;69(12):1676-9.Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus. |
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