| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T40149 | ||||
| Target Name | mRNA of human PKC-eta | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | BALANOL | Drug Info | IC50 = 20 nM | ||
| PROSTRATIN | Drug Info | Ki = 190 nM | [527606] | ||
| 8-Octyl-benzolactam-V9 | Drug Info | Ki = 144 nM | [528158] | ||
| LY-326449 | Drug Info | IC50 = 300 nM | [534154] | ||
| References | |||||
| Ref 527606 | J Med Chem. 1992 May 29;35(11):1978-86.A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. | ||||
| Ref 528158 | J Med Chem. 2006 May 4;49(9):2681-8.Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. | ||||
| Ref 534154 | J Med Chem. 1996 Jul 5;39(14):2664-71.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. | ||||
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