| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T14834 | ||||
| Target Name | Cytosolic phospholipase A2 | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | [3,4''']biflavone | Drug Info | IC50 = 8420 nM | [529028] | |
| [6,4''']biflavone | Drug Info | IC50 = 11900 nM | [529028] | ||
| WAY-196025 | Drug Info | IC50 = 10 nM | [529940] | ||
| ECOPLADIB | Drug Info | IC50 = 150 nM | [529940] | ||
| EFIPLADIB | Drug Info | IC50 = 40 nM | [529940] | ||
| 4-(2-oxohexadecanamido)butanoic acid | Drug Info | IC50 = 4400 nM | [528680] | ||
| ARACHIDONYL TRIFLUOROMETHYLKETONE | Drug Info | IC50 = 2300 nM | [530576] | ||
| 1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one | Drug Info | IC50 = 500 nM | [530576] | ||
| [4',4''']-biflavone | Drug Info | IC50 = 6000 nM | [529028] | ||
| [6,3''']biflavone | Drug Info | IC50 = 16800 nM | [529028] | ||
| AR-C70484XX | Drug Info | IC50 = 11 nM | [530576] | ||
| References | |||||
| Ref 529028 | Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. Epub 2007 Aug 22.Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. | ||||
| Ref 529028 | Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. Epub 2007 Aug 22.Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. | ||||
| Ref 529940 | J Med Chem. 2009 Feb 26;52(4):1156-71.Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. | ||||
| Ref 529940 | J Med Chem. 2009 Feb 26;52(4):1156-71.Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. | ||||
| Ref 529940 | J Med Chem. 2009 Feb 26;52(4):1156-71.Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. | ||||
| Ref 528680 | J Med Chem. 2007 Mar 22;50(6):1380-400. Epub 2007 Feb 17.Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. | ||||
| Ref 530576 | Bioorg Med Chem. 2010 Jan 15;18(2):945-52. Epub 2009 Nov 17.1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amidehydrolase. | ||||
| Ref 530576 | Bioorg Med Chem. 2010 Jan 15;18(2):945-52. Epub 2009 Nov 17.1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amidehydrolase. | ||||
| Ref 529028 | Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. Epub 2007 Aug 22.Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. | ||||
| Ref 529028 | Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. Epub 2007 Aug 22.Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. | ||||
| Ref 530576 | Bioorg Med Chem. 2010 Jan 15;18(2):945-52. Epub 2009 Nov 17.1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amidehydrolase. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.