Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T06671 | Target Info | |||
| Target Name | Interleukin-18 (IL18) | ||||
| Synonyms |
Interleukin-1 gamma; Interferon-gamma inducing factor; Interferon gamma-inducing factor; Iboctadekin; IL1F4; IL-18; IL-1 gamma; IGIF; IFN-gamma-inducing factor
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| Target Type | Clinical trial Target | ||||
| Gene Name | IL18 | ||||
| Biochemical Class | Cytokine: interleukin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Angiotensinogenase renin (REN) | Successful Target | ||||
| UniProt ID | RENI_HUMAN | |||||
| Gene Name | REN | |||||
| Synonyms |
Renin; Angiotensinogenase
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | Ki = 100 nM | [1] | ||
| Co-Target Name | Cathepsin D (CTSD) | Clinical trial Target | ||||
| UniProt ID | CATD_HUMAN | |||||
| Gene Name | CTSD | |||||
| Synonyms |
CPSD; CD
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 0.0016 ug.mL-1 | [2] | ||
| Co-Target Name | Cathepsin L (CTSL) | Clinical trial Target | ||||
| UniProt ID | CATL1_HUMAN | |||||
| Gene Name | CTSL | |||||
| Synonyms |
Major excreted protein; MEP; Cathepsin L1; CTSL1
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 800 nM | [3] | ||
| Co-Target Name | Plasmodium Plasmepsin 2 (Malaria PLA2) | Patented-recorded Target | ||||
| UniProt ID | PLM2_PLAFA | |||||
| Gene Name | Malaria PLA2 | |||||
| Synonyms |
Plasmepsin-2; PFAPD; Aspartic hemoglobinase II
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 0.42 nM | [4] | ||
| Co-Target Name | Cathepsin E (CTSE) | Literature-reported Target | ||||
| UniProt ID | CATE_HUMAN | |||||
| Gene Name | CTSE | |||||
| Synonyms |
Cathepsin E
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 0.08 nM | [5] | ||
| Co-Target Name | Plasmodium Plasmepsin 1 (Malaria PLA1) | Literature-reported Target | ||||
| UniProt ID | PLM1_PLAFA | |||||
| Gene Name | Malaria PLA1 | |||||
| Synonyms |
Plasmepsin I; PFAPG; Aspartic hemoglobinase I
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 0.9 nM | [4] | ||
| Co-Target Name | Pepsinogen-5 (PGA5) | Literature-reported Target | ||||
| UniProt ID | PEPA5_HUMAN | |||||
| Gene Name | PGA5 | |||||
| Synonyms |
Pepsin A-5
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 59 nM | [6] | ||
| Co-Target Name | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) | Co-Target | ||||
| UniProt ID | ADAM9_HUMAN | |||||
| Gene Name | ADAM9 | |||||
| Synonyms |
ADAM 9; Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase
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| Representative Drug(s) | Iboctadekin + rituximab | Drug Info | IC50 = 56.3 nM | [7] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61. | ||||
| REF 2 | Inhibition of Cathepsin D protease activity by. Med Chem Res. 2012 Dec 18;22:3953-8. | ||||
| REF 3 | Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem. 2009 May 14;52(9):3093-7. | ||||
| REF 4 | 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. Bioorg Med Chem. 2018 May 15;26(9):2488-2500. | ||||
| REF 5 | Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium. Bioorg Med Chem. 2016 Aug 1;24(15):3276-82. | ||||
| REF 6 | Auxiliary agents for the peroral administration of peptide and protein drugs: synthesis and evaluation of novel pepstatin analogues. J Med Chem. 1998 Jun 18;41(13):2339-44. | ||||
| REF 7 | Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. | ||||
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