Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Co-Targets
Target Regulators
Target Profiles in Patients
Target Affiliated Biological Pathways
Target-Related Models and Studies
References
Drug Binding Sites of Target  Top
Ligand Name: Chaps Ligand Info
Structure Description Crystal structure of human interleukin-18 PDB:3WO2
Method X-ray diffraction Resolution 2.33 Å Mutation No [14]
PDB Sequence
YFGKLESKLS
10
VIRNLNDQVL
20
FIDQGNRPLF
30
EDMTDSDCRD
40
NAPRTIFIIS
50

MYKDSQPRGM
60
AVTISVKCEK
70
ISTLSCENKI
80
ISFKEMNPPD
90
NIKDTKSDII
100

FFQRSVPGHD
110
NKMQFESSSY
120
EGYFLACEKE
130
RDLFKLILKK
140
EDELGDRSIM
150

FTVQNED
Residue
Distance (Å)
LYS4
3.698
SER7
3.383
LYS8
4.595
LEU9
3.804
SER10
4.369
VAL11
3.874
ARG13
4.359
ASP35
3.508
CYS38
3.739
ARG39
4.024
ASP40
4.978
ALA42
3.913
Residue
Distance (Å)
PRO43
3.692
THR45
4.590
ILE46
3.858
ILE48
3.678
LYS67
3.302
ILE71
3.088
ASN87
3.728
PRO88
3.722
GLN154
3.000
ASN155
3.432
GLU156
3.319
ASP157
4.142
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
Cytokine-cytokine receptor interaction hsa04060 Affiliated Target
  Class: Environmental Information Processing => Signaling molecules and interaction Pathway Hierarchy
Viral protein interaction with cytokine and cytokine receptor hsa04061 Affiliated Target
  Class: Environmental Information Processing => Signaling molecules and interaction Pathway Hierarchy
NOD-like receptor signaling pathway hsa04621 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Cytosolic DNA-sensing pathway hsa04623 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Degree 28 Degree centrality 3.01E-03 Betweenness centrality 5.75E-04
Closeness centrality 2.20E-01 Radiality 1.39E+01 Clustering coefficient 3.47E-01
Neighborhood connectivity 2.31E+01 Topological coefficient 1.03E-01 Eccentricity 11
Download Click to Download the Full PPI Network of This Target

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