Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T26623 Target Info
Target Name Aldose reductase (AKR1B1)
Synonyms
Aldehyde reductase; AKR1B1
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Target Type Successful Target
Gene Name AKR1B1
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
ALDR_HUMAN
Co-Targets of This Target  Top
Co-Target Name Carbonic anhydrase XII (CA-XII) Successful Target
UniProt ID CAH12_HUMAN
Gene Name CA12
Synonyms
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 52.1 nM [1]
Co-Target Name Carbonic anhydrase IV (CA-IV) Successful Target
UniProt ID CAH4_HUMAN
Gene Name CA4
Synonyms
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 75.7 nM [1]
Co-Target Name Strychnine-binding glycine receptor (GLRA1) Successful Target
UniProt ID GLRA1_HUMAN
Gene Name GLRA1
Synonyms
Strychnine-insensitive glycine receptor; Strychnine binding subunit; Glycine receptor 48 kDa subunit; GLRA1
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Representative Drug(s) Drug Info EC50 = 380 nM [2]
Co-Target Name Carbonic anhydrase II (CA-II) Successful Target
UniProt ID CAH2_HUMAN
Gene Name CA2
Synonyms
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 410 nM [1]
Co-Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target
UniProt ID KDM1A_HUMAN
Gene Name KDM1A
Synonyms
Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
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Representative Drug(s) CONTIGOSIDE B Drug Info IC50 = 950 nM [3]
Co-Target Name Carbonic anhydrase VII (CA-VII) Patented-recorded Target
UniProt ID CAH7_HUMAN
Gene Name CA7
Synonyms
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 3.8 nM [1]
Co-Target Name Aldo-keto reductase family 1 member B10 (AKR1B10) Co-Target
UniProt ID AK1BA_HUMAN
Gene Name AKR1B10
Synonyms
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
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Representative Drug(s) SSR-125047 Drug Info IC50 = 11.6 nM Click to Show More [4]
2 Epalrestat Drug Info IC50 = 330 nM [5]
Co-Target Name Aldo-keto reductase family 1 member A1 (AKR1A1) Co-Target
UniProt ID AK1A1_HUMAN
Gene Name AKR1A1
Synonyms
Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase
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Representative Drug(s) SSR-125047 Drug Info IC50 = 720 nM [5]
References  Top
REF 1 New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem. 2015 Nov 15;23(22):7219-25.
REF 2 Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor alpha1 for the treatment of pain. J Med Chem. 2015 Apr 9;58(7):2958-66.
REF 3 Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro. Bioorg Med Chem. 2019 Jan 15;27(2):370-374.
REF 4 Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9.
REF 5 Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem. 2010 Apr 1;18(7):2485-90.

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