Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T60529 Target Info
Target Name Prostaglandin G/H synthase 1 (COX-1)
Synonyms
Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PHS 1; PGHS-1; PGH synthase 1; Cyclooxygenase-1; COX1; COX-1
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Target Type Successful Target
Gene Name PTGS1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
PGH1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Dipeptidyl peptidase 4 (DPP-4) Successful Target
UniProt ID DPP4_HUMAN
Gene Name DPP4
Synonyms
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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Representative Drug(s) Drug Info IC50 = 0.6 nM [1]
Co-Target Name Prostaglandin G/H synthase 2 (COX-2) Successful Target
UniProt ID PGH2_HUMAN
Gene Name PTGS2
Synonyms
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2
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Representative Drug(s) Flufenamic Acid Drug Info IC50 = 16 nM Click to Show More [2]
2 Drug Info IC50 = 750 nM [9]
3 Naproxen Drug Info IC50 = 900 nM [5]
Co-Target Name Aromatase (CYP19A1) Successful Target
UniProt ID CP19A_HUMAN
Gene Name CYP19A1
Synonyms
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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Representative Drug(s) Drug Info IC50 ~ 40 ug.mL-1 [3]
Co-Target Name Dihydrodiol dehydrogenase type I (AKR1C3) Successful Target
UniProt ID AK1C3_HUMAN
Gene Name AKR1C3
Synonyms
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Testosterone 17-beta-dehydrogenase 5; Prostaglandin F synthase; PGFS; KIAA0119; Indanol dehydrogenase; HSD17B5; HA1753; Dihydrodiol dehydrogenase 3; DDH1; DD3; DD-3; Chlordecone reductase homolog HAKRb; Aldo-keto reductase family 1 member C3; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type II, brain; 3-alpha-HSD type 2; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5
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Representative Drug(s) Flufenamic Acid Drug Info IC50 = 50 nM Click to Show More [2]
2 Naproxen Drug Info IC50 = 180 nM [5]
Co-Target Name Quinone reductase 2 (NQO2) Successful Target
UniProt ID NQO2_HUMAN
Gene Name NQO2
Synonyms
Quinone oxidoreductase 2; Qui reductase 2; QR2; NRH:quinone oxidoreductase 2; NRH:qui oxidoreductase 2; NQO2; NAD(P)H qui oxidoreductase 2
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Representative Drug(s) Drug Info Ki = 88 nM [4]
Co-Target Name PI3-kinase alpha (PIK3CA) Successful Target
UniProt ID PK3CA_HUMAN
Gene Name PIK3CA
Synonyms
p110alpha; Serine/threonine protein kinase PIK3CA; PtdIns3kinase subunit p110alpha; PtdIns3kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; PtdIns-3-kinase subunit alpha; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PI3kinase subunit alpha; PI3Kalpha; PI3K-alpha; PI3-kinase subunit alpha
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Representative Drug(s) Drug Info IC50 = 250 nM [6]
Co-Target Name Amyloid beta A4 protein (APP) Successful Target
UniProt ID A4_HUMAN
Gene Name APP
Synonyms
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
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Representative Drug(s) Curcumin Drug Info IC50 = 630 nM [7]
Co-Target Name Monoamine oxidase type A (MAO-A) Successful Target
UniProt ID AOFA_HUMAN
Gene Name MAOA
Synonyms
Monoamine oxidase A; Amine oxidase [flavin-containing] A
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Representative Drug(s) Curcumin Drug Info Ki = 710 nM [8]
Co-Target Name Transformation-sensitive protein p120 (TRPA1) Successful Target
UniProt ID TRPA1_HUMAN
Gene Name TRPA1
Synonyms
TRPA1; Ankyrin-like with transmembrane domains protein 1; ANKTM1
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Representative Drug(s) Drug Info IC50 = 750 nM [10]
Co-Target Name Estrogen receptor (ESR) Successful Target
UniProt ID ESR1_HUMAN
Gene Name ESR1
Synonyms
Nuclear receptor subfamily 3 group A member 1; NR3A1; Estradiol receptor; ESR; ER-alpha; ER
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Representative Drug(s) Drug Info Ki = 785 nM [11]
Co-Target Name Carbonic anhydrase XIV (CA-XIV) Successful Target
UniProt ID CAH14_HUMAN
Gene Name CA14
Synonyms
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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Representative Drug(s) Drug Info Ki = 830 nM [12]
Co-Target Name Carbonic anhydrase XII (CA-XII) Successful Target
UniProt ID CAH12_HUMAN
Gene Name CA12
Synonyms
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) Drug Info Ki = 950 nM [12]
Co-Target Name Lactoylglutathione lyase (GLO1) Clinical trial Target
UniProt ID LGUL_HUMAN
Gene Name GLO1
Synonyms
S-D-lactoylglutathione methylglyoxal lyase; Methylglyoxalase; Ketone-aldehyde mutase; Glyoxalase I; GlxI; Glx I; GLO1; Aldoketomutase
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Representative Drug(s) Curcumin Drug Info Ki = 5 nM [13]
Co-Target Name Tissue factor (F3) Successful Target
UniProt ID TF_HUMAN
Gene Name F3
Synonyms
Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen
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Representative Drug(s) Curcumin Drug Info IC50 = 13.16 nM [14]
Co-Target Name Prostaglandin E synthase (PTGES) Clinical trial Target
UniProt ID PTGES_HUMAN
Gene Name PTGES
Synonyms
p53-induced gene 12 protein; PIG12; PGES; PGE synthase; P53-induced apoptosis protein 12; Microsomal prostaglandin E synthase 1; Microsomal glutathione S-transferase 1-like 1; MPGES1; MPGES-1; MGST1L1; MGST1-L1
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Representative Drug(s) Curcumin Drug Info IC50 = 200 nM [15]
Co-Target Name PI3-kinase beta (PIK3CB) Clinical trial Target
UniProt ID PK3CB_HUMAN
Gene Name PIK3CB
Synonyms
p110beta; PtdIns3kinase subunit p110beta; PtdIns3kinase subunit beta; PtdIns-3-kinase subunit p110-beta; PtdIns-3-kinase subunit beta; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunitbeta isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalyticsubunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PIK3C1; PI3kinase subunit beta; PI3Kbeta; PI3K-beta; PI3-kinase subunit beta
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Representative Drug(s) Drug Info IC50 = 500 nM [6]
Co-Target Name Cytochrome P450 1B1 (CYP1B1) Clinical trial Target
UniProt ID CP1B1_HUMAN
Gene Name CYP1B1
Synonyms
CYPIB1
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Representative Drug(s) Drug Info Ki = 750 nM [16]
Co-Target Name Carbonic anhydrase IX (CA-IX) Clinical trial Target
UniProt ID CAH9_HUMAN
Gene Name CA9
Synonyms
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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Representative Drug(s) Drug Info Ki = 810 nM [12]
Co-Target Name CDGSH iron-sulfur domain-containing protein 1 (CISD1_HUMAN) Co-Target
UniProt ID CISD1_HUMAN
Gene Name CISD1
Synonyms
MitoNEET
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Representative Drug(s) Curcumin Drug Info Ki = 101 nM [17]
Co-Target Name Thiosulfate sulfurtransferase (TST) Co-Target
UniProt ID THTR_HUMAN
Gene Name TST
Synonyms
Rhodanese
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Representative Drug(s) Mesalazine Drug Info IC50 = 280 nM [18]
Co-Target Name Aldo-keto reductase family 1 member C2 (AKR1C2) Co-Target
UniProt ID AK1C2_HUMAN
Gene Name AKR1C2
Synonyms
Dihydrodiol dehydrogenase 2; DD-2; DD2; 3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Type III 3-alpha-hydroxysteroid dehydrogenase
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Representative Drug(s) Flufenamic Acid Drug Info IC50 = 370 nM [2]
Co-Target Name Aldo-keto reductase family 1 member B10 (AKR1B10) Co-Target
UniProt ID AK1BA_HUMAN
Gene Name AKR1B10
Synonyms
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
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Representative Drug(s) Flufenamic Acid Drug Info IC50 = 760 nM [19]
References  Top
REF 1 Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2018 May 10;151:145-157.
REF 2 Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem. 2012 Mar 8;55(5):2311-23.
REF 3 Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93.
REF 4 Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorg Med Chem. 2013 Oct 1;21(19):6022-37.
REF 5 Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. J Med Chem. 2016 Aug 25;59(16):7431-44.
REF 6 Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55.
REF 7 Neuritogenic activity of bi-functional bis-tryptoline triazole. Bioorg Med Chem. 2017 Feb 1;25(3):1195-1201.
REF 8 Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis. ACS Med Chem Lett. 2015 Dec 1;7(1):56-61.
REF 9 Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43.
REF 10 Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3167-72.
REF 11 Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.
REF 12 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
REF 13 Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243.
REF 14 Microbial hydroxylation and glycosylation of pentacyclic triterpenes as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1026-30.
REF 15 Targeting microsomal prostaglandin E2 synthase-1 (mPGES-1): the development of inhibitors as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs). Medchemcomm. 2015;6:2081-123.
REF 16 Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. Eur J Med Chem. 2019 Feb 1;163:28-36.
REF 17 Identification of small molecules that bind to the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5350-5353.
REF 18 HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1;29(9):1106-1112.
REF 19 Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. J Nat Prod. 2015 Nov 25;78(11):2666-74.

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