Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76369 | Target Info | |||
| Target Name | Liver carboxylesterase (CES1) | ||||
| Synonyms |
Serine esterase 1; Monocyte/macrophage serine esterase; Human carboxylesterase 1; HMSE; HCE1; CES1; Brain carboxylesterase hBr1; Acyl coenzyme A:cholesterol acyltransferase
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| Target Type | Successful Target | ||||
| Gene Name | CES1 | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Sterol O-acyltransferase 1 (SOAT1) | Co-Target | ||||
| UniProt ID | SOAT1_HUMAN | |||||
| Gene Name | SOAT1 | |||||
| Synonyms |
Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1
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| Representative Drug(s) | PACTIMIBE | Drug Info | IC50 = 300 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and b... J Med Chem. 2008 Aug 14;51(15):4823-33. | ||||
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