Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T84780 | Target Info | |||
Target Name | Cellular inhibitor of apoptosis 1 (BIRC2) | ||||
Synonyms |
hIAP2; hIAP-2; TNFR2TRAFsignaling complex protein 2; TNFR2-TRAF-signaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; CIAP1; C-IAP1; Baculoviral IAP repeatcontaining protein 2; Baculoviral IAP repeat-containing protein 2; API1
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Target Type | Clinical trial Target | ||||
Gene Name | BIRC2 | ||||
Biochemical Class | Acyltransferase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Cellular inhibitor of apoptosis 2 (BIRC3) | Clinical trial Target | ||||
UniProt ID | BIRC3_HUMAN | |||||
Gene Name | BIRC3 | |||||
Synonyms |
hIAP1; hIAP-1; TNFR2TRAFsignaling complex protein 1; TNFR2-TRAF-signaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; CIAP2; C-IAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
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Representative Drug(s) | AT-406 | Drug Info | Ki = 5.1 nM | [1] | ||
Co-Target Name | X-linked inhibitor of apoptosis protein (XIAP) | Clinical trial Target | ||||
UniProt ID | XIAP_HUMAN | |||||
Gene Name | XIAP | |||||
Synonyms |
hILP; hIAP3; hIAP-3; Xlinked IAP; X-linked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAPlike protein; IAP3; IAP-like protein; IAP-3; E3 ubiquitinprotein ligase XIAP; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeatcontaining protein 4; Baculoviral IAP repeat-containing protein 4; BIRC4; API3
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Representative Drug(s) | AT-406 | Drug Info | EC50 = 34 nM | [2] |
References | Top | ||||
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REF 1 | A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011 Apr 28;54(8):2714-26. | ||||
REF 2 | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. J Med Chem. 2015 Aug 27;58(16):6574-88. |
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