Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T89988 Target Info
Target Name C-C chemokine receptor type 2 (CCR2)
Synonyms
Monocyte chemoattractant protein 1 receptor; MCP-1-R; Chemokine receptor CCR2B; CMKBR2; CD192; CCR-2; CC-CKR-2; C-C CKR-2
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Target Type Clinical trial Target
Gene Name CCR2
Biochemical Class GPCR rhodopsin
UniProt ID
CCR2_HUMAN
Co-Targets of This Target  Top
Co-Target Name C-C chemokine receptor type 5 (CCR5) Successful Target
UniProt ID CCR5_HUMAN
Gene Name CCR5
Synonyms
HIV-1 fusion coreceptor; HIV-1 fusion co-receptor; Chemokine receptor CCR5; CMKBR5; CHEMR13; CD195 antigen; CD195; CCR-5; CC-CKR-5; C-C CKR-5
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Representative Drug(s) Drug Info IC50 = 3 nM [1]
Co-Target Name C-C chemokine receptor type 7 (CCR7) Literature-reported Target
UniProt ID CCR7_HUMAN
Gene Name CCR7
Synonyms
MIP3 beta receptor; MIP-3 beta receptor; EpsteinBarr virusinduced Gprotein coupled receptor 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; EBVinduced Gprotein coupled receptor 1; EBV-induced G-protein coupled receptor 1; EBI1; CMKBR7; CDw197; CD197; CCR-7; CCCKR7; CC-CKR-7; CC chemokine receptor type 7; CC CKR7; C-C CKR-7; BLR2
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Representative Drug(s) Drug Info IC50 = 3.1 nM [2]
Co-Target Name Diamine oxidase (AOC1) Literature-reported Target
UniProt ID AOC1_HUMAN
Gene Name AOC1
Synonyms
Kidney amine oxidase; KAO; Histaminase; Amiloride-binding protein; AOC1; ABP
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Representative Drug(s) Drug Info Ki = 140 nM [3]
References  Top
REF 1 Chemokine receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9363-92.
REF 2 The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem. 2020 May 28;63(10):5031-5073.
REF 3 Synthesis of 4(5)-imidazolyl allylamines and propargylamines as inhibitors of diamine oxidase. Bioorg Med Chem Lett. 1993 Feb;3(2):353-6.

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