Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T92777 Target Info
Target Name Intestinal maltase-glucoamylase (MGAM)
Synonyms
MGAM
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Target Type Successful Target
Gene Name MGAM
Biochemical Class Glycosylase
UniProt ID
MGA_HUMAN
Co-Targets of This Target  Top
Co-Target Name Lysosomal alpha-glucosidase (GAA) Successful Target
UniProt ID LYAG_HUMAN
Gene Name GAA
Synonyms
GAA; Aglucosidase alfa; Acid maltase
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Representative Drug(s) Deoxynojirimycin Drug Info IC50 = 60 nM Click to Show More [1]
2 Voglibose Drug Info IC50 = 70 nM [1]
3 Miglitol Drug Info IC50 = 350 nM [1]
Co-Target Name Neutral alpha-glucosidase AB (GANAB) Co-Target
UniProt ID GANAB_HUMAN
Gene Name GANAB
Synonyms
Glucosidase II subunit alpha; Alpha-glucosidase 2
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Representative Drug(s) Deoxynojirimycin Drug Info Ki = 14 nM [2]
Co-Target Name Sucrase-isomaltase (SI) Co-Target
UniProt ID SUIS_HUMAN
Gene Name SI
Synonyms
Sucrase-isomaltase, intestinal
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Representative Drug(s) Miglitol Drug Info IC50 = 500 nM [3]
References  Top
REF 1 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
REF 2 Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin. Bioorg. Med. Chem. Lett. 1992;2:27-32.
REF 3 Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010 Jan 28;53(2):689-98.

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