Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93878 | Target Info | |||
| Target Name | Solute carrier family 12 member 1 (SLC12A1) | ||||
| Synonyms |
Solute carrier family 12 member; SLC12A1; Na+/K+/2CL- co-transporter; NKCC2; Kidney-specific Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)Solute carrier family 12 member 1-chloride cotransporter 2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
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| Target Type | Successful Target | ||||
| Gene Name | SLC12A1 | ||||
| Biochemical Class | Cation-chloride cotransporter | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Mineralocorticoid receptor (MR) | Successful Target | ||||
| UniProt ID | MCR_HUMAN | |||||
| Gene Name | NR3C2 | |||||
| Synonyms |
Nuclear receptor subfamily 3 group C member 2; Mineralocorticoid receptor; MLR; MCR; Inner ear mineralocorticoid receptor; Delta
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| Representative Drug(s) | Aldosterone | Drug Info | EC50 = 0.18 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
| UniProt ID | CAH12_HUMAN | |||||
| Gene Name | CA12 | |||||
| Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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| Representative Drug(s) | Chlorthalidone | Drug Info | Ki = 4.5 nM | Click to Show More | [2] | |
| 2 | Furosemide | Drug Info | Ki = 261 nM | [2] | ||
| 3 | Drug Info | Ki = 312 nM | [2] | |||
| Co-Target Name | Carbonic anhydrase XIV (CA-XIV) | Successful Target | ||||
| UniProt ID | CAH14_HUMAN | |||||
| Gene Name | CA14 | |||||
| Synonyms |
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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| Representative Drug(s) | Furosemide | Drug Info | Ki = 52 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase I (CA-I) | Successful Target | ||||
| UniProt ID | CAH1_HUMAN | |||||
| Gene Name | CA1 | |||||
| Synonyms |
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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| Representative Drug(s) | Furosemide | Drug Info | Ki = 62 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 345 nM | [2] | |||
| 3 | Chlorthalidone | Drug Info | Ki = 348 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
| UniProt ID | CAH2_HUMAN | |||||
| Gene Name | CA2 | |||||
| Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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| Representative Drug(s) | Furosemide | Drug Info | Ki = 65 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 91 nM | [2] | |||
| 3 | Chlorthalidone | Drug Info | Ki = 138 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase IV (CA-IV) | Successful Target | ||||
| UniProt ID | CAH4_HUMAN | |||||
| Gene Name | CA4 | |||||
| Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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| Representative Drug(s) | Chlorthalidone | Drug Info | Ki = 196 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 449 nM | [2] | |||
| 3 | Furosemide | Drug Info | Ki = 564 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase VI (CA-VI) | Successful Target | ||||
| UniProt ID | CAH6_HUMAN | |||||
| Gene Name | CA6 | |||||
| Synonyms |
Secreted carbonic anhydrase; Salivary carbonic anhydrase; Carbonic anhydrase 6; Carbonate dehydratase VI
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| Representative Drug(s) | Furosemide | Drug Info | Ki = 245 nM | [2] | ||
| Co-Target Name | Corticosteroid-binding globulin (SERPINA6) | Successful Target | ||||
| UniProt ID | CBG_HUMAN | |||||
| Gene Name | SERPINA6 | |||||
| Synonyms |
Transcortin; SERPINA6; CBG
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| Representative Drug(s) | Aldosterone | Drug Info | Ki = 524.81 nM | [3] | ||
| Co-Target Name | Carbonic anhydrase IX (CA-IX) | Clinical trial Target | ||||
| UniProt ID | CAH9_HUMAN | |||||
| Gene Name | CA9 | |||||
| Synonyms |
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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| Representative Drug(s) | Chlorthalidone | Drug Info | Ki = 23 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 87 nM | [2] | |||
| 3 | Furosemide | Drug Info | Ki = 420 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
| UniProt ID | CAH7_HUMAN | |||||
| Gene Name | CA7 | |||||
| Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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| Representative Drug(s) | Chlorthalidone | Drug Info | Ki = 2.8 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 7.9 nM | [2] | |||
| 3 | Furosemide | Drug Info | Ki = 513 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase VB (CA5B) | Co-Target | ||||
| UniProt ID | CAH5B_HUMAN | |||||
| Gene Name | CA5B | |||||
| Synonyms |
Carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA-VB
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| Representative Drug(s) | Chlorthalidone | Drug Info | Ki = 9 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 134 nM | [2] | |||
| 3 | Furosemide | Drug Info | Ki = 322 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase VA (CA5A) | Co-Target | ||||
| UniProt ID | CAH5A_HUMAN | |||||
| Gene Name | CA5A | |||||
| Synonyms |
Carbonic anhydrase 5A, mitochondrial; Carbonate dehydratase VA; CA-VA
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| Representative Drug(s) | Furosemide | Drug Info | Ki = 499 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 763 nM | [2] | |||
| 3 | Chlorthalidone | Drug Info | Ki = 917 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORbeta and RORgammat. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5265-7. | ||||
| REF 2 | Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. | ||||
| REF 3 | Comparative molecular active site analysis (CoMASA). 1. An approach to rapid evaluation of 3D QSAR. J Med Chem. 2004 May 20;47(11):2732-42. | ||||
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