Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95289 | Target Info | |||
| Target Name | Retinoic acid receptor RXR (RXR) | ||||
| Synonyms |
RXR
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| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | ||||
| UniProt ID | PPARG_HUMAN | |||||
| Gene Name | PPARG | |||||
| Synonyms |
PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
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| Representative Drug(s) | IRX4204 | Drug Info | EC50 = 8.6 nM | [1] | ||
| Co-Target Name | Retinoic acid receptor alpha (RARA) | Clinical trial Target | ||||
| UniProt ID | RARA_HUMAN | |||||
| Gene Name | RARA | |||||
| Synonyms |
RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
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| Representative Drug(s) | IRX-5183 | Drug Info | EC50 = 200 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4071-5. | ||||
| REF 2 | Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8. | ||||
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