Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01JGV
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| Former ID |
DNAP001616
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| Drug Name |
Ajmalicine
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| Synonyms |
MLS000111555; methyl 19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate; NSC72115; SMR000107477; Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19.alpha.)-; 6474-90-4; WLN: T F6 D5 C666 EM ON SO TU& TTTJ R1 UVO1; Isoarteril; Oxayohimban-16-carboxylic acid,17-didehydro-19-methyl-, methyl ester, (19
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| Drug Type |
Small molecular drug
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| Indication | Circulatory disorder [ICD-11: BE2Z] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H24N2O3
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| Canonical SMILES |
CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45
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| InChI |
1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1
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| InChIKey |
GRTOGORTSDXSFK-XJTZBENFSA-N
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| CAS Number |
CAS 483-04-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
114926, 114938, 400025, 3498439, 5381153, 7977315, 8138368, 8138377, 9397932, 10523828, 10589097, 11445844, 11445867, 14900932, 30049750, 49908753, 51071925, 57400548, 58003974, 76413967, 81041172, 85209801, 88961357, 92221568, 93576886, 103828520, 104445554, 105277899, 117551855, 118490164, 118980383, 124659233, 124813117, 125321929, 125351251, 126424550, 126448986, 126469248, 127996783, 135894816, 137009041, 143725030, 162220009, 164806067, 169959173, 179226193, 217582612, 225209848, 226649216, 242052838
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| ChEBI ID |
CHEBI:2524
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. | |||
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