Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D05USL
|
|||
Former ID |
DNC007250
|
|||
Drug Name |
KU-55933
|
|||
Synonyms |
KU-55933; 587871-26-9; ATM Kinase Inhibitor; KU55933; 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one; 2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one; KU 55933; 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; UNII-O549494L5D; CHEMBL222102; KU-55933 (ATM Kinase Inhibitor); O549494L5D; 2-morpholino-6-thianthren-1-yl-pyran-4-one; 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one; 4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-; AC1NQSSP; PubChem22474; cc-73; SCHEMBL1984941; GTPL5928
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C21H17NO3S2
|
|||
Canonical SMILES |
C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
|
|||
InChI |
1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
|
|||
InChIKey |
XRKYMMUGXMWDAO-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 587871-26-9
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
7844841, 8615301, 11114627, 11164641, 14781018, 26758160, 29203552, 39287686, 46391370, 46493711, 57357692, 75370431, 85083135, 98629299, 99302612, 99436975, 103511262, 104085576, 113847780, 117682509, 124756991, 125163796, 125503170, 126626060, 126658559, 126665902, 126729190, 131480676, 134344455, 134964017, 135272753, 135685400, 135685401, 135685420, 135686218, 135686219, 135686234, 135686235, 135698625, 136340184, 136367291, 136367904, 136920401, 137054921, 139118899, 143496651, 144116111, 152234890, 152258339, 152344221
|
|||
ChEBI ID |
CHEBI:91372
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [2] |
KEGG Pathway | Non-homologous end-joining | |||
Cell cycle | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
Coregulation of Androgen receptor activity | ||||
Class I PI3K signaling events mediated by Akt | ||||
BARD1 signaling events | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | |||
WikiPathways | DNA Damage Response | |||
Non-homologous end joining | ||||
FAS pathway and Stress induction of HSP regulation | ||||
Cytosolic sensors of pathogen-associated DNA | ||||
Retinoblastoma (RB) in Cancer | ||||
Prostate Cancer | ||||
Double-Strand Break Repair | ||||
Cell Cycle | ||||
miRNA Regulation of DNA Damage Response |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5928). | |||
REF 2 | Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.