Drug Information
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
|
Studied Microbe: Adlercreutzia equolifaciens
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[4] | |||
| Hierarchy | ||||
| Resulting Metabolite | Dihydroresveratrol | |||
| Description | Trans-resveratrol can be metabolized to Dihydroresveratrol by Adlercreutzia equolifaciens. | |||
|
Studied Microbe: Slackia equolifaciens
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[4] | |||
| Hierarchy | ||||
| Resulting Metabolite | Dihydroresveratrol | |||
| Description | Trans-resveratrol can be metabolized to Dihydroresveratrol by Slackia equolifaciens. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Resulting Metabolite | 3,4'-dihydroxy-trans-stilbene; 3,4'-dihydroxybibenzyl | |||
| Description | Trans-resveratrol can be metabolized to 3,4'-dihydroxy-trans-stilbene and 3,4'-dihydroxybibenzyl by gut microbiota. | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Rat | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Bacteroides was decreased by Resveratrol (p < 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Kunming mice | Experimental Sample | Colonic content | |
| Disease or Condition | High fat induced obesity | |||
| Description | The abundance of Bifidobacterium was increased by Resveratrol. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Desulfovibrionales | ||||
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Studied Microbe: Desulfovibrionaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Rat | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Desulfovibrionaceae was decreased by Resveratrol (p < 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Rat | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Blautia was increased by Resveratrol (p < 0.05). | |||
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Studied Microbe: Dorea
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Rat | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Dorea was increased by Resveratrol (p < 0.01). | |||
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Studied Microbe: Ruminococcus gnavus
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[7] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Colitis | |||
| Description | The abundance of Ruminococcus gnavus was increased by Resveratrol (p < 0.05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Kunming mice | Experimental Sample | Colonic content | |
| Disease or Condition | High fat induced obesity | |||
| Description | The abundance of Enterococcus faecalis was decreased by Resveratrol. | |||
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Studied Microbe: Lactobacillus
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Kunming mice | Experimental Sample | Colonic content | |
| Disease or Condition | High fat induced obesity | |||
| Description | The abundance of Lactobacillus was increased by Resveratrol. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Kunming mice | Experimental Sample | Colonic content | |
| Disease or Condition | High fat induced obesity | |||
| Description | The abundance of Akkermansia was increased by Resveratrol. | |||
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Studied Microbe: Akkermansia muciniphila
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[7] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Colitis | |||
| Description | The abundance of Akkermansia muciniphila was increased by Resveratrol (p < 0.05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Firmicutes/Bacteroidetes ratio
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|
[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Kunming mice | Experimental Sample | Colonic content | |
| Disease or Condition | High fat induced obesity | |||
| Description | The abundance of Firmicutes/Bacteroidetes ratio was decreased by Resveratrol. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | NAD-dependent deacetylase sirtuin-1 (SIRT1) | Target Info | Inhibitor | [9] |
| Prostaglandin G/H synthase 1 (COX-1) | Target Info | Modulator | [10] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018787) | |||
| REF 4 | In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. Am J Clin Nutr. 2013 Feb;97(2):295-309. | |||
| REF 5 | Sinapic acid and resveratrol alleviate oxidative stress with modulation of gut microbiota in high-fat diet-fed rats. Food Res Int. 2019 Feb;116:1202-1211. | |||
| REF 6 | Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity. Food Funct. 2014 Jun;5(6):1241-9. | |||
| REF 7 | Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells. J Leukoc Biol. 2019 Aug;106(2):467-480. | |||
| REF 8 | Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling. Nutrients. 2020 Jan 1;12(1):119. | |||
| REF 9 | Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. | |||
| REF 10 | Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37. | |||
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