Drug Information
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Alistipes indistinctus DSM22520
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.377; p = 0.003). | |||
|
Studied Microbe: Bacteroides cellulosilyticus DSM 14838
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -4.23; p = 0.003). | |||
|
Studied Microbe: Bacteroides coprophilus DSM 18228
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -6.018; p = 0.001). | |||
|
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -8.699; p = 0.003). | |||
|
Studied Microbe: Bacteroides eggerthii DSM20697
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -4.737; p = 0.007). | |||
|
Studied Microbe: Bacteroides fragilis ATCC43859
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -11.194; p = 0.001). | |||
|
Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -7.198; p = 0.001). | |||
|
Studied Microbe: Bacteroides fragilis HMW 615
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -3.726; p = 0.004). | |||
|
Studied Microbe: Bacteroides fragilis NCTC 9343
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -7.304; p = 0.002). | |||
|
Studied Microbe: Bacteroides fragilis str. 3397 T10
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -9.985; p = 0.002). | |||
|
Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -5.379; p = 0.003). | |||
|
Studied Microbe: Bacteroides fragilis str. DS-208
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -8.232; p = 0.003). | |||
|
Studied Microbe: Bacteroides intestinalis DSM 17393
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -6.287; p = 0.0). | |||
|
Studied Microbe: Bacteroides ovatus ATCC 8483
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -3.049; p = 0.01). | |||
|
Studied Microbe: Bacteroides stercoris ATCC 43183
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -9.163; p = 0.002). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 3731
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.772; p = 0.001). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 7330
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.525; p = 0.0). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.714; p = 0.0). | |||
|
Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -5.075; p = 0.001). | |||
|
Studied Microbe: Bacteroides vulgatus ATCC 8482
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -9.9; p = 0.004). | |||
|
Studied Microbe: Bacteroides WH2
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides WH2 (log2FC = -6.449; p = 0.002). | |||
|
Studied Microbe: Bacteroides xylanisolvens DSM18836
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -3.4; p = 0.0). | |||
|
Studied Microbe: Odoribacter splanchnicus
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Odoribacter splanchnicus (log2FC = -8.091; p = 0.002). | |||
|
Studied Microbe: Parabacteroides distasonis ATCC 8503
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -7.602; p = 0.001). | |||
|
Studied Microbe: Parabacteroides johnsonii DSM 18315
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -6.742; p = 0.001). | |||
|
Studied Microbe: Parabacteroides merdae ATCC 43184
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -5.485; p = 0.002). | |||
|
Studied Microbe: Pretovella copri DSM 18205
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.634; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Clostridium spiroforme DSM1552
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -1.675; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Clostridium sporogenes ATCC 15579
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -1.025; p = 0.003). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Modulator | [2] |
| Serotonin transporter (SERT) | Target Info | Modulator | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7427). | |||
| REF 2 | 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.