Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00VXM
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| Former ID |
DIB019782
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| Drug Name |
droxinostat
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| Synonyms |
NS-41080; NS41080
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C11H14ClNO3
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| Canonical SMILES |
CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
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| InChI |
1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
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| InChIKey |
JHSXDAWGLCZYSM-UHFFFAOYSA-N
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| CAS Number |
CAS 99873-43-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3395519, 4294610, 7976312, 8089390, 8683016, 11177099, 12240829, 16777079, 17457418, 40378155, 47868302, 48769034, 49763171, 74777775, 87926768, 99437145, 105767842, 113490614, 117934896, 121361124, 124757236, 124781334, 124889779, 125164040, 130982904, 131480871, 134964552, 136340192, 136367418, 136367960, 136946693, 137052797, 139550249, 144047742, 144115925, 152258505, 160644544, 160647340, 162011831, 162037593, 162202706, 164193979, 164914325, 169565171, 174531821, 175608163, 175614199, 179179626, 185965244, 228463896
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| ChEBI ID |
CHEBI:94504
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histone deacetylase 3 (HDAC3) | Target Info | Inhibitor | [1] |
| Histone deacetylase 6 (HDAC6) | Target Info | Inhibitor | [1] | |
| Histone deacetylase 8 (HDAC8) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Thyroid hormone signaling pathway | |||
| Alcoholism | ||||
| Viral carcinogenesis | ||||
| Panther Pathway | Wnt signaling pathway | |||
| Pathway Interaction Database | Signaling events mediated by HDAC Class II | |||
| Signaling events mediated by HDAC Class I | ||||
| Retinoic acid receptors-mediated signaling | ||||
| Validated targets of C-MYC transcriptional repression | ||||
| Regulation of retinoblastoma protein | ||||
| Reactome | NOTCH1 Intracellular Domain Regulates Transcription | |||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
| HDACs deacetylate histones | ||||
| Assembly of the primary cilium | ||||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| Neural Crest Differentiation | ||||
| Cell Cycle | ||||
| Ectoderm Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56. | |||
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