Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01FLN
|
|||
| Former ID |
DIB007368
|
|||
| Drug Name |
LX-2932
|
|||
| Synonyms |
S1P lyase inhibitor (autoimmune diseases), Lexicon; Sphingosine-1-phosphate lyase inhibitor (autoimmune diseases), Lexicon
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Autoimmune diabetes [ICD-11: 5A10] | Terminated | [1] | |
| Company |
Lexicon Pharmaceuticals Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C10H13N3O5
|
|||
| Canonical SMILES |
C1=CON=C1C2=NC=C(N2)C(C(C(CO)O)O)O
|
|||
| InChI |
1S/C10H13N3O5/c14-4-7(15)9(17)8(16)6-3-11-10(12-6)5-1-2-18-13-5/h1-3,7-9,14-17H,4H2,(H,11,12)/t7-,8-,9-/m1/s1
|
|||
| InChIKey |
WGDPRIZUIYIENM-IWSPIJDZSA-N
|
|||
| CAS Number |
CAS 1055027-48-9
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sphingosine-1-phosphate lyase 1 (SGPL1) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Sphingolipid metabolism | |||
| Metabolic pathways | ||||
| Sphingolipid signaling pathway | ||||
| Pathwhiz Pathway | Sphingolipid Metabolism | |||
| Pathway Interaction Database | Sphingosine 1-phosphate (S1P) pathway | |||
| Reactome | Sphingolipid de novo biosynthesis | |||
| WikiPathways | Sphingolipid metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021957) | |||
| REF 2 | Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932). J Med Chem. 2010 Dec 23;53(24):8650-62. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.