Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01LFA
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| Former ID |
DIB001150
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| Drug Name |
ARX-201
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| Synonyms |
PEG-ahGH; PEG-hGH variants (growth disorders), Ambrx; PEG-human growth hormone variants (ReCODE, growth disorders), Ambrx; 30KPEG-N1-pAFhGH; 30PEG-N4-pAFhGH
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| Indication | Growth failure [ICD-11: LD2F.1Y] | Discontinued in Phase 2 | [1] | |
| Company |
Ambrx Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Somatotropin (GH1) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Neuroactive ligand-receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Reactome | Prolactin receptor signaling | |||
| Growth hormone receptor signaling | ||||
| WikiPathways | Endochondral Ossification | |||
| Prolactin receptor signaling | ||||
| Growth hormone receptor signaling | ||||
| Adipogenesis | ||||
| Synthesis, Secretion, and Deacylation of Ghrelin | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022324) | |||
| REF 2 | Company report (Avarx) | |||
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