Drug Information
Drug General Information | Top | |||
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Drug ID |
D02KIE
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Former ID |
DNAP001548
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Drug Name |
Cimetropium bromide
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Synonyms |
Alginor (TN)
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Drug Type |
Small molecular drug
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Indication | Gastric motility disorder [ICD-11: DA21; ICD-10: K22.4] | Approved | [1] | |
Spasm [ICD-11: MB47.3; ICD-10: R25.2] | Approved | [1] | ||
Company |
DeAngelini
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Structure |
Download2D MOL
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Formula |
C21H28BrNO4
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Canonical SMILES |
C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4)CC5CC5.[Br-]
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InChI |
1S/C21H28NO4.BrH/c1-22(11-13-7-8-13)17-9-15(10-18(22)20-19(17)26-20)25-21(24)16(12-23)14-5-3-2-4-6-14;/h2-6,13,15-20,23H,7-12H2,1H3;1H/q+1;/p-1/t15?,16-,17-,18+,19-,20+,22?;/m1./s1
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InChIKey |
WDURTRGFUGAJHA-HNHWXVNLSA-M
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CAS Number |
CAS 51598-60-8
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
SuperDrug ATC ID |
A03BB05
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Target and Pathway | Top | |||
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Target(s) | Muscarinic acetylcholine receptor M5 (CHRM5) | Target Info | Modulator | [2], [3] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Cholinergic synapse | ||||
Regulation of actin cytoskeleton | ||||
Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Reactome | Muscarinic acetylcholine receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
Regulation of Actin Cytoskeleton | ||||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
REF 3 | Scopolamine in Brugmansia suaveolens (Solanaceae): defense, allocation, costs, and induced response. J Chem Ecol. 2007 Feb;33(2):297-309. |
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