Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02UFQ
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| Former ID |
DCL000649
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| Drug Name |
TAK-285
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| Synonyms |
TAK-285; 871026-44-7; TAK 285; TAK285; UNII-70CCB438L6; N-(2-(4-(3-CHLORO-4-(3-(TRIFLUOROMETHYL)PHENOXY)PHENYLAMINO)-5H-PYRROLO[3,2-D]PYRIMIDIN-5-YL)ETHYL)-3-HYDROXY-3-METHYLBUTANAMIDE; CHEMBL1614725; 70CCB438L6; N-{2-[4-({3-Chloro-4-[3-(Trifluoromethyl)phenoxy]phenyl}amino)-5h-Pyrrolo[3,2-D]pyrimidin-5-Yl]ethyl}-3-Hydroxy-3-Methylbutanamide; n-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5h-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide; C26H25ClF3N5O3
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H25ClF3N5O3
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| Canonical SMILES |
CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O
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| InChI |
1S/C26H25ClF3N5O3/c1-25(2,37)14-22(36)31-9-11-35-10-8-20-23(35)24(33-15-32-20)34-17-6-7-21(19(27)13-17)38-18-5-3-4-16(12-18)26(28,29)30/h3-8,10,12-13,15,37H,9,11,14H2,1-2H3,(H,31,36)(H,32,33,34)
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| InChIKey |
ZYQXEVJIFYIBHZ-UHFFFAOYSA-N
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| CAS Number |
CAS 871026-44-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16723798, 23729055, 76528874, 117636547, 123085234, 126723029, 136946475, 136962454, 137415944, 152159596, 152258643, 160647478, 160657298, 162011635, 163642792, 170483702, 170483947, 172919601, 174006544, 174531123, 184823669, 196409688, 198935983, 208013301, 223705277, 224135473, 227239043, 242060025, 246781978, 252473546, 252543424
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| Drug Resistance Mutation (DRM) | Top | |||
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| DRM | DRM Info | |||
| References | Top | |||
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| REF 1 | ClinicalTrials.gov (NCT00535522) A Safety and Pharmacokinetic Study of TAK-285 in Patients With Advanced Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Takeda (2009). | |||
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