Drug Information
Drug General Information | Top | |||
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Drug ID |
D02ZJI
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Former ID |
DNC000873
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Drug Name |
Levalbuterol
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Synonyms |
Levosalbutamol; 34391-04-3; (R)-salbutamol; Xopenex; R-Salbutamol; R-Albuterol; (r)-(-)-salbutamol; UNII-EDN2NBH5SS; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; EDN2NBH5SS; CHEBI:8746; Levosalbutamol (INN); Levosalbutamol [INN]; (R)-albuterol; m-Xylene-alpha,alpha'-diol, alpha(sup 1)-((tert-butylamino)methyl)-4-hydroxy-, (R)-(-)-; (-)-alpha(sup 1)-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol
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Drug Type |
Small molecular drug
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Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Approved | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C13H21NO3
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Canonical SMILES |
CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O
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InChI |
1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/m0/s1
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InChIKey |
NDAUXUAQIAJITI-LBPRGKRZSA-N
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CAS Number |
CAS 34391-04-3
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PubChem Compound ID | ||||
PubChem Substance ID |
13934, 10240794, 10852016, 11111805, 11111806, 11112645, 11113612, 14798337, 26744252, 29303834, 49879812, 50071332, 57340474, 77876163, 93166666, 96024814, 99036159, 99234398, 99774850, 103266935, 103911314, 104418876, 117814444, 124881447, 125325478, 126524239, 126670038, 128684762, 131311264, 131835145, 135078939, 135376066, 136965309, 137001318, 139121247, 164795671, 175267044, 175269554, 177748808, 179150348, 184546277, 223519271, 223668238, 223982365, 226396078, 252091683, 252166097
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ChEBI ID |
CHEBI:8746
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ADReCS Drug ID | BADD_D01262 ; BADD_D01263 ; BADD_D01264 | |||
SuperDrug ATC ID |
R03AC02
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SuperDrug CAS ID |
cas=018559949
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Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor beta-2 (ADRB2) | Target Info | Antagonist | [3] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Endocytosis | ||||
Adrenergic signaling in cardiomyocytes | ||||
Salivary secretion | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Beta2 adrenergic receptor signaling pathway | ||||
Pathway Interaction Database | Arf6 trafficking events | |||
Arf6 signaling events | ||||
Reactome | Adrenoceptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
GPCRs, Class A Rhodopsin-like | ||||
Vitamin D Receptor Pathway | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005434) | |||
REF 3 | Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8. |
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