Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03MCV
|
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| Former ID |
DCL000212
|
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| Drug Name |
RB-006
|
|||
| Indication | Coronary artery disease [ICD-11: BA80; ICD-10: I25.1] | Discontinued in Phase 3 | [1] | |
| Thrombosis [ICD-11: DB61-GB90] | Discontinued in Phase 3 | [1] | ||
| Vascular disease [ICD-11: BE2Z] | Discontinued in Phase 3 | [1] | ||
| Company |
Regado Biosci
|
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| Structure |
 |
Download2D MOL
|
||
| Formula |
C20H39N3NaO11P
|
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| Canonical SMILES |
COCCOC(=O)NCCCCC(C(=O)NCCCCCCOP(=O)(O)[O-])NC(=O)OCCOC.[Na+]
|
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| InChI |
1S/C20H40N3O11P.Na/c1-30-13-15-32-19(25)22-11-7-5-9-17(23-20(26)33-16-14-31-2)18(24)21-10-6-3-4-8-12-34-35(27,28)29;/h17H,3-16H2,1-2H3,(H,21,24)(H,22,25)(H,23,26)(H2,27,28,29);/q;+1/p-1
|
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| InChIKey |
AYPFBAOWSFOSKF-UHFFFAOYSA-M
|
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| CAS Number |
CAS 959716-32-6
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Coagulation factor IX (F9) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Panther Pathway | Blood coagulation | |||
| Pathwhiz Pathway | Coagulation | |||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | |||
| Intrinsic Pathway of Fibrin Clot Formation | ||||
| Gamma-carboxylation of protein precursors | ||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
| Blood Clotting Cascade | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019932) | |||
| REF 2 | In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. Thromb Haemost. 2009 May;101(5):827-33. | |||
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