Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03OMK
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| Former ID |
DIB001757
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| Drug Name |
DM-107
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| Synonyms |
MDPK-67; MDPK-67b; Kallikrein 2 inhibitor (anticancer), Med Discovery; Kallikrein 2 inhibitor (dermatological disorders), Dermadis
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| Indication | Atopic dermatitis [ICD-11: EA80; ICD-10: L20; ICD-9: 691.8, 692.9] | Investigative | [1] | |
| Company |
Med Discovery SA
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tissue kallikrein (KLK2) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Coregulation of Androgen receptor activity | |||
| Regulation of Androgen receptor activity | ||||
| Reactome | Activation of Matrix Metalloproteinases | |||
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
| WikiPathways | Prostate Cancer | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2372). | |||
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