Drug Information
Drug General Information | Top | |||
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Drug ID |
D04PHG
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Former ID |
DIB018565
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Drug Name |
2-methyl-3-phenethyl-3H-pyrimidin-4-one
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Synonyms |
compound 2H [PMID: 15863312]
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H21FN2O2
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Canonical SMILES |
CCC1=C(N=C(N(C1=O)CCC2=CC=CC=C2F)C3=CC=CC=C3O)C
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InChI |
1S/C21H21FN2O2/c1-3-16-14(2)23-20(17-9-5-7-11-19(17)25)24(21(16)26)13-12-15-8-4-6-10-18(15)22/h4-11,25H,3,12-13H2,1-2H3
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InChIKey |
JYFJNCCRKBBRKZ-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Extracellular calcium-sensing receptor (CASR) | Target Info | Antagonist | [1] |
Pathway Interaction Database | E-cadherin signaling in keratinocytes | |||
Reactome | G alpha (q) signalling events | |||
G alpha (i) signalling events | ||||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones. Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40. |
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