Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05PZZ
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| Former ID |
DIB016380
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| Drug Name |
DDP-200
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| Synonyms |
Overactive bladder therapeutics, Dynogen
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| Indication | Urinary incontinence [ICD-11: MF50.2; ICD-9: 788.3] | Discontinued in Phase 2 | [1] | |
| Company |
Dynogen
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Muscarinic acetylcholine receptor M5 (CHRM5) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Cholinergic synapse | ||||
| Regulation of actin cytoskeleton | ||||
| Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Muscarinic acetylcholine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| Regulation of Actin Cytoskeleton | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020170) | |||
| REF 2 | CA patent application no. 753057, Sustained release oral dosage forms of an r-baclofen prodrug. | |||
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