Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A8HN
|
|||
| Former ID |
DNCL002483
|
|||
| Drug Name |
Iboctadekin
|
|||
| Indication | Non-hodgkin lymphoma [ICD-11: 2B33.5; ICD-10: C85.9] | Phase 1 | [1] | |
| Ovarian cancer [ICD-11: 2C73; ICD-10: C56] | Phase 1 | [1] | ||
| Company |
GlaxoSmithKline
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin-18 (IL18) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| NOD-like receptor signaling pathway | ||||
| Cytosolic DNA-sensing pathway | ||||
| Salmonella infection | ||||
| Legionellosis | ||||
| African trypanosomiasis | ||||
| Malaria | ||||
| Tuberculosis | ||||
| Influenza A | ||||
| Inflammatory bowel disease (IBD) | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Panther Pathway | Interleukin signaling pathway | |||
| Toll receptor signaling pathway | ||||
| Pathway Interaction Database | IL27-mediated signaling events | |||
| IL12-mediated signaling events | ||||
| IL23-mediated signaling events | ||||
| Cellular roles of Anthrax toxin | ||||
| IL12 signaling mediated by STAT4 | ||||
| Reactome | Interleukin-1 processing | |||
| WikiPathways | Hypertrophy Model | |||
| IL1 and megakaryotyces in obesity | ||||
| Corticotropin-releasing hormone | ||||
| NOD pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008435) | |||
| REF 2 | Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study. Cancer Immunol Res. 2013 Sep;1(3):168-78. | |||
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