Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IJ2H
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| Former ID |
DIB001212
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| Drug Name |
FK-584
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| Synonyms |
4,4-Diphenylcyclopentenylamine hydrochloride; 2-Cyclopenten-1-amine, 4,4-diphenyl-, hydrochloride; 4,4-diphenyl-2-cyclopentenylamine; FK 584; 56740-43-3; AC1L57OZ; LS-58284; 4,4-diphenylcyclopent-2-en-1-amine hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Central and peripheral nervous disease [ICD-11: 8A04-8E7Z; ICD-10: G96.9] | Discontinued in Phase 2 | [1] | |
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C21H25N
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| Canonical SMILES |
CC(C)(C)NC1CC(C=C1)(C2=CC=CC=C2)C3=CC=CC=C3
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| InChI |
1S/C21H25N/c1-20(2,3)22-19-14-15-21(16-19,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-15,19,22H,16H2,1-3H3/t19-/m1/s1
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| InChIKey |
QMTVTICJRCJOFZ-LJQANCHMSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Muscarinic acetylcholine receptor M5 (CHRM5) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Cholinergic synapse | ||||
| Regulation of actin cytoskeleton | ||||
| Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Muscarinic acetylcholine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| Regulation of Actin Cytoskeleton | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006686) | |||
| REF 2 | US patent application no. 2005,0261,328, Pharmaceutical composition comprising beta-3-adrenoceptor-agonists and antimuscarinic agents. | |||
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