Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J7BH
|
|||
| Former ID |
DNC004764
|
|||
| Drug Name |
4-Morpholin-4-yl-chromen-2-one
|
|||
| Synonyms |
4-Morpholin-4-yl-chromen-2-one; 4-morpholin-4-ylchromen-2-one; CHEMBL367262; 65625-83-4; 4-morpholinyl coumarin; SMR000116476; AC1LFJN6; CBMicro_022351; Oprea1_628619; Oprea1_860966; MLS000526002; SCHEMBL11450752; 4-morpholino-2H-chromen-2-one; CTK1I2254; DTXSID30355510; MolPort-001-959-554; ZINC312514; HMS2490I17; CCG-9410; BDBM50159613; AKOS000639877; 4-(4-morpholinyl)-2H-chromen-2-one; MCULE-8859511318; BAS 01256112; BIM-0022285.P001; ST50008215; 2H-1-Benzopyran-2-one, 4-(4-morpholinyl)-; SR-01000312410; AI-204/31682008
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C13H13NO3
|
|||
| Canonical SMILES |
C1COCCN1C2=CC(=O)OC3=CC=CC=C32
|
|||
| InChI |
1S/C13H13NO3/c15-13-9-11(14-5-7-16-8-6-14)10-3-1-2-4-12(10)17-13/h1-4,9H,5-8H2
|
|||
| InChIKey |
YJXJQEJDZPLPTQ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 65625-83-4
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.