Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J9XZ
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| Former ID |
DAP000745
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| Drug Name |
Torasemide
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| Synonyms |
Demadex; Dilutol; Luprac; Presoril; Sutril; TORSEMIDE; Toradiur; Torasemida; Torasemidum; Torem; Torocard; Torrem; Unat; Torasemide N; Torsemide [USAN]; AC 4464; BM 02015; JDL 464; BM-02015; Demadex (TN); Demadex, Torsemide; GJ-1090; JDL-464; KS-1123; Luprac (TN); PW-2132; Torasemida [INN-Spanish]; Torasemidum [INN-Latin]; Torsemide (USP); Torasemide (JAN/INN); N-(Isopropylcarbamoyl)-4-(m-tolylamino)pyridine-3-sulfonamide; N-{[(1-methylethyl)amino]carbonyl}-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide; N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide; 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea; 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea; 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea; 1-isopropyl-3-[(4-m-toluidino-3-pyridyl) sulfonyl]urea
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| Drug Type |
Small molecular drug
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| Indication | Congestive heart failure [ICD-11: BD10; ICD-10: I50.0] | Approved | [1], [2] | |
| Therapeutic Class |
Diuretics
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| Structure |
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Download2D MOL |
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| Formula |
C16H20N4O3S
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| Canonical SMILES |
CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C
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| InChI |
1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
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| InChIKey |
NGBFQHCMQULJNZ-UHFFFAOYSA-N
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| CAS Number |
CAS 56211-40-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7585786, 7847448, 8177279, 11112793, 11364670, 11367232, 11369794, 11373102, 11373959, 11377957, 11467058, 11468178, 11484799, 11486816, 11488958, 11491647, 11492105, 11495590, 11528723, 12012656, 14900728, 25819958, 26612831, 26680347, 26719820, 26748988, 26748989, 34707389, 46386585, 46504760, 47291390, 47515595, 47515596, 47736767, 48259511, 48334790, 48416649, 49665992, 49666477, 49681707, 49699258, 49833537, 50107501, 53789088, 56313713, 57312605, 80124867, 81040892, 85788916, 87560438
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| ChEBI ID |
CHEBI:9637
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| ADReCS Drug ID | BADD_D02251 ; BADD_D02413 | |||
| SuperDrug ATC ID |
C03CA04
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| SuperDrug CAS ID |
cas=056211406
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Solute carrier family 12 member 1 (SLC12A1) | Target Info | Blocker | [3], [4], [5] |
| KEGG Pathway | Salivary secretion | |||
| Pancreatic secretion | ||||
| Vibrio cholerae infection | ||||
| Pathwhiz Pathway | Kidney Function | |||
| Reactome | Cation-coupled Chloride cotransporters | |||
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7312). | |||
| REF 2 | Drug information of Torasemide, 2008. eduDrugs. | |||
| REF 3 | Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9. | |||
| REF 4 | Effects of loop diuretics on angiotensin II-stimulated vascular smooth muscle cell growth. Nephrol Dial Transplant. 2001;16 Suppl 1:14-7. | |||
| REF 5 | Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats. Hypertension. 1999 Jul;34(1):138-43. | |||
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