Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L3TX
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| Former ID |
DNC004765
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| Drug Name |
4-Piperidin-1-yl-chromen-2-one
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| Synonyms |
4-Piperidin-1-yl-chromen-2-one; CHEMBL176114; 4-piperidinocoumarin; AC1LEH6J; 4-piperidylchromen-2-one; Oprea1_207466; Oprea1_800231; MLS000711082; 4-piperidin-1-ylchromen-2-one; ZINC53303; HMS2627L16; BDBM50159626; AKOS003620982; MCULE-1716733202; 4-(1-piperidinyl)-2H-chromen-2-one; BAS 01052429; SMR000280849; ST50993947; EU-0085678; SR-01000527828
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H15NO2
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| Canonical SMILES |
C1CCN(CC1)C2=CC(=O)OC3=CC=CC=C32
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| InChI |
1S/C14H15NO2/c16-14-10-12(15-8-4-1-5-9-15)11-6-2-3-7-13(11)17-14/h2-3,6-7,10H,1,4-5,8-9H2
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| InChIKey |
AZAXRUNIGYYEKS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | |||
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