Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ND2J
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| Former ID |
DAP001114
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| Drug Name |
Flavoxate
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| Synonyms |
Bladuril; Flavossato; Flavoxato; Flavoxatum; Urispas; Flavossato [DCIT]; Flavoxate HCI; Flavoxate HCL; Spasuret hydrochloride; AK 123; Bladderon (TN); Bladuril (TN); DW-61; Flavoxate (INN); Flavoxate [INN:BAN]; Flavoxato [INN-Spanish]; Flavoxatum [INN-Latin]; Urispas (TN); Uritac (TN); Zopyran-8-carboxylate; Beta-piperidinoethyl 3-methylflavone-8-carboxylate; Piperidinoethyl-3-methylflavone-8-carboxylate; 1-Piperidinoethanol, 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate; 2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylat; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate; 2-Piperidinoethyl-3-methyl-4-oxo-2-phenyl-4H-1-ben; 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate; 2-piperidinoethyl 3-methylflavone-8-carboxylate; 4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Dysuria [ICD-11: MF50.7; ICD-10: R30.0] | Approved | [1] | |
| Nocturia [ICD-11: MF55; ICD-10: R35] | Approved | [1] | ||
| Suprapubic pain [ICD-11: MG30-MG3Z] | Approved | [1] | ||
| Urgency [ICD-11: N.A.] | Approved | [1] | ||
| Therapeutic Class |
Parasympatholytics
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| Company |
Nippon Shinyaku
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H25NO4
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| Canonical SMILES |
CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4
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| InChI |
1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3
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| InChIKey |
SPIUTQOUKAMGCX-UHFFFAOYSA-N
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| CAS Number |
CAS 15301-69-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10011, 222481, 5319184, 7979228, 8152134, 10508998, 11112543, 11466270, 11467390, 11485979, 14780778, 29222489, 46505138, 47736652, 47736653, 47885570, 48185150, 48259425, 48416012, 49698402, 49831132, 49889157, 74703718, 85209796, 85788471, 96024656, 103555996, 104303266, 111978146, 114916870, 124882441, 124882442, 125536623, 127346290, 127346291, 129269473, 134223534, 134338359, 134992694, 137005165, 142085579, 152106493, 160964482, 162174319, 163693538, 164831967, 172873816, 175266323, 178103762, 179149988
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| ChEBI ID |
CHEBI:5088
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| ADReCS Drug ID | BADD_D00900 ; BADD_D00901 | |||
| SuperDrug ATC ID |
G04BD02
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| SuperDrug CAS ID |
cas=015301696
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Muscarinic acetylcholine receptor M5 (CHRM5) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Cholinergic synapse | ||||
| Regulation of actin cytoskeleton | ||||
| Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Muscarinic acetylcholine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| Regulation of Actin Cytoskeleton | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res. 1996 Jul 15;727(1-2):91-8. | |||
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