Drug Information
Drug General Information | Top | |||
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Drug ID |
D0OK5I
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Former ID |
DAP000836
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Drug Name |
Tridihexethyl
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Synonyms |
Pathilon; Propethonum; (3-cyclohexyl-3-hydroxy-3-phenylpropyl)-triethylazanium; 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium
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Drug Type |
Small molecular drug
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Indication | Acquired nystagmus [ICD-11: 9C84; ICD-10: H55-H59, H55; ICD-9: 379.5] | Approved | [1] | |
Therapeutic Class |
Anticholinergic Agents
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Structure |
Download2D MOL |
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Formula |
C21H36NO+
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Canonical SMILES |
CC[N+](CC)(CC)CCC(C1CCCCC1)(C2=CC=CC=C2)O
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InChI |
1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1
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InChIKey |
NPRHVSBSZMAEIN-UHFFFAOYSA-N
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CAS Number |
CAS 60-49-1
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:9701
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SuperDrug ATC ID |
A03AB08
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SuperDrug CAS ID |
cas=000060491
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Target and Pathway | Top | |||
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Target(s) | Muscarinic acetylcholine receptor M5 (CHRM5) | Target Info | Binder | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Cholinergic synapse | ||||
Regulation of actin cytoskeleton | ||||
Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Reactome | Muscarinic acetylcholine receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
Regulation of Actin Cytoskeleton | ||||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009489. | |||
REF 2 | Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41. |
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