Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P8QN
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| Former ID |
DIB010807
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| Drug Name |
Recombinant Factor IX
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| Synonyms |
RFIX, Baxter; Recombinant Factor IX, Baxter
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| Indication | Bleeding disorder [ICD-11: GA20-GA21] | Approved | [1] | |
| Factor IX deficiency [ICD-11: 3B11; ICD-10: D67] | Terminated | [2] | ||
| Company |
Baxter 1nternational
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Coagulation factor IX (F9) | Target Info | Modulator | [3] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Panther Pathway | Blood coagulation | |||
| Pathwhiz Pathway | Coagulation | |||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | |||
| Intrinsic Pathway of Fibrin Clot Formation | ||||
| Gamma-carboxylation of protein precursors | ||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
| Blood Clotting Cascade | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | DAILYMED.nlm.nih.gov:IXINITY- coagulation factor ix (recombinant) | |||
| REF 2 | Clinical pipeline report, company report or official report of Baxter 1nternational. | |||
| REF 3 | BAX326 (RIXUBIS): a novel recombinant factor IX for the control and prevention of bleeding episodes in adults and children with hemophilia B. Ther Adv Hematol. 2014 Oct;5(5):168-80. | |||
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