Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U0RJ
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| Former ID |
DNCL002766
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| Drug Name |
Leukocyte interleukin
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| Synonyms |
Multikine (TN)
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| Indication | Head and neck cancer [ICD-11: 2D42] | Phase 1 | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62] | Phase 1 | [1] | ||
| Company |
CEL-SCI
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 2 receptor beta (IL2RB) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Endocytosis | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Measles | ||||
| HTLV-I infection | ||||
| Transcriptional misregulation in cancer | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Interleukin signaling pathway | |||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| SHP2 signaling | ||||
| IL2-mediated signaling events | ||||
| IL2 signaling events mediated by PI3K | ||||
| IL2 signaling events mediated by STAT5 | ||||
| Downstream signaling in naï | ||||
| Reactome | GPVI-mediated activation cascade | |||
| G beta:gamma signalling through PI3Kgamma | ||||
| Interleukin-2 signaling | ||||
| RAF/MAP kinase cascade | ||||
| Interleukin receptor SHC signaling | ||||
| WikiPathways | IL-2 Signaling Pathway | |||
| Inflammatory Response Pathway | ||||
| Interleukin-2 signaling | ||||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02115919) Safety Study of Multikine in the Treatment of Perianal Warts. U.S. National Institutes of Health. | |||
| REF 2 | Leukocyte Interleukin, Inj. (LI) augmentation of natural killer cells and cytolytic T-lymphocytes. Immunopharmacol Immunotoxicol. 1995 May;17(2):247-64. | |||
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