Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Target Regulators
Target Profiles in Patients
Target Affiliated Biological Pathways
Target-Related Models and Studies
References
Drug Binding Sites of Target  Top
Ligand Name: Alpha-D-Mannose Ligand Info
Structure Description Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor PDB:5M5E
Method X-ray diffraction Resolution 2.30 Å Mutation No [8]
PDB Sequence
SQFTCFYNSR
15
ANISCVWSQD
25
GALQDTSCQV
35
HAWPDRRRWN
45
QTCELLPVSQ
55

ASWACNLILG
65
APDSQKLTTV
75
DIVTLRVLCR
85
EGVRWRVMAI
95
QDFKPFENLR
105

LMAPISLQVV
115
HVETHRCNIS
125
WEISQASHYF
135
ERHLEFEART
145
LSPGHTWEEA
155

PLLTLKQKQE
165
WICLETLTPD
175
TQYEFQVRVK
185
PLQGEFTTWS
195
PWSQPLAFRT
205

KPA
Residue
Distance (Å)
ARG183
3.132
LYS185
3.692
THR192
4.123
Residue
Distance (Å)
THR193
2.875
TRP194
1.553
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
Protein Name Pfam ID Percentage of Identity (%) E value
Interleukin 21 receptor (IL21R) 26.582 (84/316) 7.99E-13
Interleukin-9 receptor (IL9R) 26.481 (76/287) 7.19E-11
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
Cytokine-cytokine receptor interaction hsa04060 Affiliated Target
  Class: Environmental Information Processing => Signaling molecules and interaction Pathway Hierarchy
Viral protein interaction with cytokine and cytokine receptor hsa04061 Affiliated Target
  Class: Environmental Information Processing => Signaling molecules and interaction Pathway Hierarchy
Endocytosis hsa04144 Affiliated Target
  Class: Cellular Processes => Transport and catabolism Pathway Hierarchy
PI3K-Akt signaling pathway hsa04151 Affiliated Target
  Class: Environmental Information Processing => Signal transduction Pathway Hierarchy
JAK-STAT signaling pathway hsa04630 Affiliated Target
  Class: Environmental Information Processing => Signal transduction Pathway Hierarchy
Th1 and Th2 cell differentiation hsa04658 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Th17 cell differentiation hsa04659 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
  Click to Show/Hide the Information of Affiliated Human Pathways
Degree 15 Degree centrality 1.61E-03 Betweenness centrality 1.28E-04
Closeness centrality 2.28E-01 Radiality 1.40E+01 Clustering coefficient 4.86E-01
Neighborhood connectivity 4.09E+01 Topological coefficient 1.45E-01 Eccentricity 12
Download Click to Download the Full PPI Network of This Target

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