miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-100-5p | ||||
miRNA Stemloop AC | MI0000102 | ||||
miRNA Stemloop ID | hsa-mir-100 | ||||
Sequence | aacccguagauccgaacuugug | ||||
TTD Target(s) Regulated by This miRNA | Estrogen receptor (ESR) | Successful Target | Target Info | [1] | |
Serine/threonine-protein kinase mTOR (mTOR) | Successful Target | Target Info | [2] | ||
Insulin-like growth factor I receptor (IGF1R) | Successful Target | Target Info | [2] | ||
Fibroblast growth factor receptor 3 (FGFR3) | Successful Target | Target Info | [3] | ||
Matrix metalloproteinase-13 (MMP-13) | Clinical trial Target | Target Info | [3] | ||
RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Target Info | [4] | ||
Vascular endothelial growth factor receptor 1 (FLT-1) | Successful Target | Target Info | [5] | ||
Polo-like kinase 1 (PLK1) | Clinical trial Target | Target Info | [6] | ||
ATM serine/threonine kinase (ATM) | Clinical trial Target | Target Info | [7] | ||
Insulin-like growth factor-II (IGF2) | Clinical trial Target | Target Info | [8] | ||
C-X-C chemokine receptor type 7 (ACKR3) | Preclinical Target | Target Info | [9] | ||
Bone morphogenetic protein receptor (BMPR2) | Literature-reported Target | Target Info | [10] | ||
FK506-binding protein 5 (FKBP5) | Literature-reported Target | Target Info | [11] | ||
Cysteine-rich angiogenic inducer 61 (CYR61) | Literature-reported Target | Target Info | [12] | ||
Protein(s) Regulated by This miRNA | CTD small phosphatase-like protein | Regulated Protein | [13] | ||
E3 SUMO-protein ligase EGR2 | Regulated Protein | [3] | |||
E3 ubiquitin-protein ligase RNF144B | Regulated Protein | [15] | |||
E3 ubiquitin-protein ligase ZNRF2 | Regulated Protein | [16] | |||
Grainyhead-like protein 1 homolog | Regulated Protein | [17] | |||
Heparan sulfate glucosamine 3-O-sulfotransferase 2 | Regulated Protein | [18] | |||
Homeobox protein Hox-A1 | Regulated Protein | [19] | |||
Nuclear receptor corepressor 2 | Regulated Protein | [20] | |||
Ras-related protein Rap-1b | Regulated Protein | [21] | |||
Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Regulated Protein | [17] | |||
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Regulated Protein | [22] | |||
THAP domain-containing protein 2 | Regulated Protein | [23] | |||
Zinc finger and BTB domain-containing protein 7A | Regulated Protein | [24] | |||
Zinc finger protein 215 | Regulated Protein | [23] | |||
References | |||||
REF 1 | Significance of microRNA targeted estrogen receptor in male fertility. Iran J Basic Med Sci. 2014 Feb;17(2):81-6. | ||||
REF 2 | Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Res. 2010 Jun 1;70(11):4666-75. | ||||
REF 3 | Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82. | ||||
REF 4 | MicroRNA-99 family targets AKT/mTOR signaling pathway in dermal wound healing. PLoS One. 2013 May 28;8(5):e64434. | ||||
REF 5 | MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res. 2012 Nov 9;111(11):1421-33. | ||||
REF 6 | Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. Int J Cancer. 2010 May 1;126(9):2036-48. | ||||
REF 7 | Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J. DNA Repair (Amst). 2010 Nov 10;9(11):1170-5. | ||||
REF 8 | miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling. Oncogene. 2013 Jul 4;32(27):3306-10. | ||||
REF 9 | miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7. Oncol Rep. 2016 Jun;35(6):3453-9. | ||||
REF 10 | MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2. FEBS Lett. 2012 Jul 30;586(16):2375-81. | ||||
REF 11 | MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways. Br J Cancer. 2013 Oct 15;109(8):2189-98. | ||||
REF 12 | MicroRNA-100 inhibits osteosarcoma cell proliferation by targeting Cyr61. Tumour Biol. 2014 Feb;35(2):1095-100. | ||||
REF 13 | MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia.Oncogene. 2012 Jan 5;31(1):80-92. | ||||
REF 14 | Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82. | ||||
REF 15 | miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation.Oncogene. 2017 Feb 23;36(8):1023-1037. | ||||
REF 16 | MicroRNA-100 suppresses human osteosarcoma cell proliferation and chemo-resistance via ZNRF2.Oncotarget. 2017 May 23;8(21):34678-34686. | ||||
REF 17 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 18 | The role of miR-100-mediated Notch pathway in apoptosis of gastric tumor cells.Cell Signal. 2015 Jun;27(6):1087-101. | ||||
REF 19 | Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100.Eur J Cancer. 2014 May;50(8):1541-54. | ||||
REF 20 | microRNA-100 targets SMRT/NCOR2, reduces proliferation, and improves survival in glioblastoma animal models.PLoS One. 2013 Nov 14;8(11):e80865. | ||||
REF 21 | MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B.Oncol Rep. 2014 May;31(5):2055-62. | ||||
REF 22 | The miR-99 family regulates the DNA damage response through its target SNF2H.Oncogene. 2013 Feb 28;32(9):1164-72. | ||||
REF 23 | MicroRNA 100: a context dependent miRNA in prostate cancer. Clinics (Sao Paulo). 2013 Jun;68(6):797-802. | ||||
REF 24 | C/EBP-induced miR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer.Cancer Lett. 2015 Dec 28;369(2):376-85. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.