miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-23b-3p | ||||
miRNA Stemloop AC | MI0000439 | ||||
miRNA Stemloop ID | hsa-mir-23b | ||||
Sequence | aucacauugccagggauuaccac | ||||
miRNA General Information | |||||
miRNA Mature ID | hsa-miR-23b-3p | ||||
miRNA Stemloop AC | MI0000439 | ||||
miRNA Stemloop ID | hsa-mir-23b | ||||
Sequence | aucacauugccagggauuacc | ||||
TTD Target(s) Regulated by This miRNA | Carbonic anhydrase II (CA-II) | Successful Target | Target Info | [1] | |
Proto-oncogene c-Src (SRC) | Successful Target | Target Info | [2] | ||
Proto-oncogene c-Met (MET) | Successful Target | Target Info | [3] | ||
Urokinase-type plasminogen activator (PLAU) | Successful Target | Target Info | [4] | ||
NAD-dependent deacetylase sirtuin-1 (SIRT1) | Clinical trial Target | Target Info | [5] | ||
Gap junction alpha-1 protein (GJA1) | Clinical trial Target | Target Info | [6] | ||
Notch-1 receptor (NOTCH1) | Clinical trial Target | Target Info | [7] | ||
Notch-2 receptor (NOTCH2) | Clinical trial Target | Target Info | [8] | ||
E2F transcription factor 1 (E2F1) | Clinical trial Target | Target Info | [9] | ||
Myristoylated alanine-rich C-kinase substrate (MARCKS) | Clinical trial Target | Target Info | [10] | ||
von Hippel-Lindau disease tumor suppressor (VHL) | Patented-recorded Target | Target Info | [11] | ||
Activin receptor type IIB (ACVR2B) | Literature-reported Target | Target Info | [12] | ||
Focal adhesion kinase 2 (PTK2B) | Literature-reported Target | Target Info | [13] | ||
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | Literature-reported Target | Target Info | [14] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [15] | ||
Protein C-ets-1 (ETS1) | Literature-reported Target | Target Info | [8] | ||
High mobility group protein HMGI-C (HMGA2) | Literature-reported Target | Target Info | [16] | ||
High-mobility group protein B2 (HMGB2) | Literature-reported Target | Target Info | [17] | ||
Runt-related transcription factor 2 (RUNX2) | Literature-reported Target | Target Info | [18] | ||
Protein(s) Regulated by This miRNA | cAMP-dependent protein kinase catalytic subunit beta | Regulated Protein | [19] | ||
Cyclin-G1 | Regulated Protein | [20] | |||
Homeobox protein TGIF1 | Regulated Protein | [21] | |||
Proline-rich acidic protein 1 | Regulated Protein | [4] | |||
Ras GTPase-activating protein-binding protein 2 | Regulated Protein | [23] | |||
Ras-related protein R-Ras2 | Regulated Protein | [24] | |||
Regulator of G-protein signaling 5 | Regulated Protein | [25] | |||
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | Regulated Protein | [14] | |||
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | Regulated Protein | [14] | |||
Thioredoxin-dependent peroxide reductase, mitochondrial | Regulated Protein | [27] | |||
Transmembrane protein 64 | Regulated Protein | [28] | |||
Ubiquitin-like protein ATG12 | Regulated Protein | [29] | |||
Versican core protein | Regulated Protein | [30] | |||
Zinc finger E-box-binding homeobox 1 | Regulated Protein | [31] | |||
References | |||||
REF 1 | Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy. J Am Heart Assoc. 2014 Mar 26;3(2):e000434. | ||||
REF 2 | miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer. Cancer Res. 2012 Dec 15;72(24):6435-46. | ||||
REF 3 | Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem. 2008 Nov 28;283(48):33394-405. | ||||
REF 4 | MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells. FEBS J. 2009 Jun;276(11):2966-82. | ||||
REF 5 | miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway. Diabetologia. 2016 Mar;59(3):644-54. | ||||
REF 6 | Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells. Biosci Rep. 2015 Aug 17;35(5). pii: e00251. | ||||
REF 7 | Prediction of mammalian microRNA targets. Cell. 2003 Dec 26;115(7):787-98. | ||||
REF 8 | The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis. Oncotarget. 2015 Jul 20;6(20):18012-26. | ||||
REF 9 | Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3234-9. | ||||
REF 10 | Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal. 2014 Jul 1;7(332):ra63. | ||||
REF 11 | VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1/VEGF and -catenin/Tcf-4 signaling. Neuro Oncol. 2012 Aug;14(8):1026-36. | ||||
REF 12 | Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease. Pediatr Res. 2015 Mar;77(3):447-54. | ||||
REF 13 | miRNA expression profiling in migrating glioblastoma cells: regulation of cell migration and invasion by miR-23b via targeting of Pyk2. PLoS One. 2012;7(6):e39818. | ||||
REF 14 | The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-. Nat Med. 2012 Jul;18(7):1077-86. | ||||
REF 15 | Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer. PLoS One. 2012;7(11):e50203. | ||||
REF 16 | Mir-23b and miR-130b expression is downregulated in pituitary adenomas. Mol Cell Endocrinol. 2014 Jun 5;390(1-2):1-7. | ||||
REF 17 | Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41. | ||||
REF 18 | MicroRNA-23b is an independent prognostic marker and suppresses ovarian cancer progression by targeting runt-related transcription factor-2. FEBS Lett. 2014 May 2;588(9):1608-15. | ||||
REF 19 | The role of microRNA-23b in the differentiation of MSC into chondrocyte by targeting protein kinase A signaling.Biomaterials. 2012 Jun;33(18):4500-7. | ||||
REF 20 | MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression.J Exp Clin Cancer Res. 2016 Feb 13;35:31. | ||||
REF 21 | MicroRNA-23b-3p regulates human keratinocyte differentiation through repression of TGIF1 and activation of the TGF- SMAD2 signalling pathway.Exp Dermatol. 2017 Jan;26(1):51-57. | ||||
REF 22 | MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells. FEBS J. 2009 Jun;276(11):2966-82. | ||||
REF 23 | MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy.J Am Soc Nephrol. 2016 Sep;27(9):2597-608. | ||||
REF 24 | UVA and UVB irradiation differentially regulate microRNA expression in human primary keratinocytes.PLoS One. 2013 Dec 31;8(12):e83392. | ||||
REF 25 | MicroRNAs that target RGS5.Iran J Basic Med Sci. 2015 Feb;18(2):108-14. | ||||
REF 26 | The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-. Nat Med. 2012 Jul;18(7):1077-86. | ||||
REF 27 | MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia.Leuk Lymphoma. 2015 Feb;56(2):460-71. | ||||
REF 28 | miR-23a/b regulates the balance between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells.Bone Res. 2016 Aug 24;4:16022. | ||||
REF 29 | miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2. Cell Death Dis. 2015 May 21;6:e1766. | ||||
REF 30 | Interleukin-17A promotes tongue squamous cell carcinoma metastasis through activating miR-23b/versican pathway.Oncotarget. 2017 Jan 24;8(4):6663-6680. | ||||
REF 31 | MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer.PLoS One. 2013 Jul 2;8(7):e67686. |
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