Target Information

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Target Regulators
References
Drug Binding Sites of Target  Top
Ligand Name: Plicamycin Ligand Info
Structure Description Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC PDB:6VGG
Method X-ray diffraction Resolution 4.31 Å Mutation No [2]
PDB Sequence
AELVRTDSPN
120
FLCSVLPSHW
130
RCNKTLPVAF
140
KVVALGEVPD
150
GTVVTVMAGN
160

DENYSAELRN
170
ASAVMKNQVA
180
RFNDLRFVGR
190
SGRGKSFTLT
200
ITVFTNPPQV
210

ATYHRAIKVT
220
VDGPREP
Residue
Distance (Å)
THR135
3.002
ASP184
3.401
Residue
Distance (Å)
ARG186
3.059
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Pathway Affiliation
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Parathyroid hormone synthesis, secretion and action hsa04928 Affiliated Target
  Class: Organismal Systems => Endocrine system Pathway Hierarchy
Degree 37 Degree centrality 3.98E-03 Betweenness centrality 4.88E-03
Closeness centrality 2.56E-01 Radiality 1.44E+01 Clustering coefficient 7.96E-02
Neighborhood connectivity 4.06E+01 Topological coefficient 4.77E-02 Eccentricity 11
Download Click to Download the Full PPI Network of This Target

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.