miRNA General Information
miRNA Mature ID hsa-miR-421
miRNA Stemloop AC MI0003685
miRNA Stemloop ID hsa-mir-421
Sequence aucaacagacauuaauugggcgc
TTD Target(s) Regulated by This miRNA ATM serine/threonine kinase (ATM) Clinical trial Target Target Info [1]
Caspase-3 (CASP3) Clinical trial Target Target Info [2]
Chromobox protein homolog 7 (CBX7) Literature-reported Target Target Info [3]
Epithelial cadherin (CDH1) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA Forkhead box protein O4 Regulated Protein [5]
Mothers against decapentaplegic homolog 4 Regulated Protein [6]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Regulated Protein [7]
RNA binding motif protein, X-linked-like-1 Regulated Protein [3]
References
REF 1 ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1506-11.
REF 2 MiR-421 regulates apoptosis of BGC-823 gastric cancer cells by targeting caspase-3. Asian Pac J Cancer Prev. 2014;15(13):5463-8.
REF 3 Increased expression of miR-421 in human gastric carcinoma and its clinical association. J Gastroenterol. 2010;45(1):17-23.
REF 4 MicroRNA-421 regulated by HIF-1 promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer. Oncotarget. 2016 Apr 26;7(17):24466-82.
REF 5 miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4.Biochem Biophys Res Commun. 2013 Jun 14;435(4):745-50.
REF 6 MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer.Biochem Biophys Res Commun. 2011 Mar 25;406(4):552-7.
REF 7 MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.Biochem Biophys Res Commun. 2016 May 20;474(1):57-63.
REF 8 Increased expression of miR-421 in human gastric carcinoma and its clinical association. J Gastroenterol. 2010;45(1):17-23.

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