Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68251 | Target Info | |||
| Target Name | Matrix metalloproteinase-2 (MMP-2) | ||||
| Synonyms | TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase | ||||
| Target Type | Successful Target | ||||
| Gene Name | MMP2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2012080762 | ||||
| Title | Novel Inhibitors of Matrix Metalloproteinases. | ||||
| Abstract | The present invention relates to compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)-R5; S(O)2-R6; R2 is H, aryl, heteroaryl, Y-(CH2)r-aryl, Y-(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive. | ||||
| Applicant(s) | Pharmahungary 2000 Kft | ||||
| Representative Drug(s) | D0O8RQ | Drug Info | N.A. | [1] | |
| China National Intellectual Property Administration (CNIPA) | |||||
| Patent ID | CN102036953 | ||||
| Title | Arylsulfonamide-Based Matrix Metalloproteinase Inhibitors. | ||||
| Representative Drug(s) | D0LS4Y | Drug Info | IC50 = 53 nM | Click to Show More | [1] |
| 2 | D0S3PN | Drug Info | IC50 = 140 nM | [1] | |
| 3 | D0A9ZW | Drug Info | IC50 = 510 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. | ||||
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