Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Drug Property Profile of Target
Co-Targets
Target Poor or Non Binders
Target Regulators
Target Profiles in Patients
Target Affiliated Biological Pathways
Target-Related Models and Studies
References
Drug Binding Sites of Target  Top
Ligand Name: SC-74020 Ligand Info
Structure Description SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 PDB:1HOV
Method Solution NMR Resolution N.A. Mutation No [62]
PDB Sequence
MYNFFPRKPK
10
WDKNQITYRI
20
IGYTPDLDPE
30
TVDDAFARAF
40
QVWSDVTPLR
50

FSRIHDGEAD
60
IMINFGRWEH
70
GDGYPFDGKD
80
GLLAHAFAPG
90
TGVGGDSHFD
100

DDELWTNTSA
110
NYSLFLVAAH
120
EFGHAMGLEH
130
SQDPGALMAP
140
IYTYTKNFRL
150

SQDDIKGIQE
160
LYG
Residue
Distance (Å)
VAL42
3.261
GLY81
3.397
LEU82
2.566
LEU83
2.083
ALA84
2.131
HIS85
2.071
ALA86
3.635
PHE115
3.072
LEU116
2.596
VAL117
3.617
ALA119
3.606
HIS120
1.872
GLU121
1.987
HIS124
2.612
HIS130
2.784
PRO134
4.277
Residue
Distance (Å)
GLY135
4.854
ALA136
2.472
LEU137
2.058
MET138
4.724
ALA139
2.427
PRO140
2.726
ILE141
2.367
TYR142
2.377
THR143
2.746
TYR144
4.102
THR145
1.689
PHE148
2.039
ARG149
2.051
LEU150
2.845
SER151
4.279
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
Leukocyte transendothelial migration hsa04670 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
GnRH signaling pathway hsa04912 Affiliated Target
  Class: Organismal Systems => Endocrine system Pathway Hierarchy
Estrogen signaling pathway hsa04915 Affiliated Target
  Class: Organismal Systems => Endocrine system Pathway Hierarchy
Relaxin signaling pathway hsa04926 Affiliated Target
  Class: Organismal Systems => Endocrine system Pathway Hierarchy
Degree 23 Degree centrality 2.47E-03 Betweenness centrality 1.50E-03
Closeness centrality 2.38E-01 Radiality 1.42E+01 Clustering coefficient 1.42E-01
Neighborhood connectivity 3.22E+01 Topological coefficient 7.49E-02 Eccentricity 12
Download Click to Download the Full PPI Network of This Target

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