Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T79232 Target Info
Target Name Vasopressin V1a receptor (V1AR)
Synonyms Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a
Target Type Successful Target
Gene Name AVPR1A
Biochemical Class GPCR rhodopsin
UniProt ID
V1AR_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO050334
Title Cyclohexyl-4H,6H-5-Oxa-2,3,10B-Triaza-Benzo[E]Azulenes As V1A Antagonists.
Applicant(s) Hoffmann-La Roche Ag
Representative Drug(s) D0LZ5Q Drug Info pKi = 9.1 [1]
United States Patent and Trademark Office (USPTO)
Patent ID US8222202
Title Use of Peptidic Vasopressin Receptor Agonists.
Applicant(s) Ferring Bv
Representative Drug(s) D0TV9B Drug Info EC50 = 1.47 nM Click to Show More [1]
2 D03TLQ Drug Info EC50 = 2.02 nM [1]
Patent ID US8148319
Title Peptidic Vasopressin Receptor Agonists.
Applicant(s) Ferring Bv
Representative Drug(s) D0TV9B Drug Info EC50 = 1.47 nM Click to Show More [1]
2 D03TLQ Drug Info EC50 = 2.02 nM [1]
Patent ID US8492376
Title Heteroarylcyclohexyl-Tetraazabenzo[E]Azulenes.
Applicant(s) Hoffmann-La Roche, Inc
Representative Drug(s) D0GT5M Drug Info pKi = 9.54 [1]
Patent ID US8461152
Title Arylcyclohexylethers of Dihydrotetraazabenzoazulenes.
Applicant(s) Hoffmann-La Roche, Inc
Representative Drug(s) D07WNO Drug Info pKi = 9.39 [1]
Patent ID US20150073032
Title Pyrrolidine Derivatives As Oxytocin/Vasopressin 1A Receptors Antagonists.
Applicant(s) Obseva Sa
Representative Drug(s) D0BU3L Drug Info Ki = 120 nM [2]
Patent ID US0079333
Title Oxy-Cyclohexyl-4H,6H-5-Oxa-2,3,10B-Triaza-Benzo[E]Azulenes As V1A Antagonists.
Applicant(s) Hoffmann-La Roche Ag
Representative Drug(s) D0MQ6T Drug Info pKi = 9.75 [1]
Patent ID US8202858
Title Vasopressin V1A Antagonists.
Applicant(s) Vantia Ltd
Representative Drug(s) D01GCI Drug Info N.A. [1]
European Patent Office (EPO)
Patent ID EP1449844
Title Benzamide Derivatives As Oxytocin Agonists and Vasopressin Antagonists.
Applicant(s) Ferring Bv
Representative Drug(s) D0H9AU Drug Info N.A. [1]
References  Top
REF 1 Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22.
REF 2 A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290.

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