Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T83011 Target Info
Target Name Monoamine oxidase type B (MAO-B)
Synonyms MAO-B; Amine oxidase [flavin-containing] B
Target Type Successful Target
Gene Name MAOB
Biochemical Class CH-NH(2) donor oxidoreductase
UniProt ID
AOFB_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2014107771
Title Substituted Indazole or Indole Derivatives As In Vitro Mao-B Inhibitors.
Abstract Substituted indazole or imidazole derivatives of formula I as in vitro selective and reversible MAO-B inhibitors and for use in the prevention and treatment of meurodegenerative disorders such as Parkinson's disease, Alzheimer's disase and dementia.
Applicant(s) Ntz Lab Ltd
Representative Drug(s) D04FJY Drug Info IC50 = 0.02 nM Click to Show More [1]
2 D01JDK Drug Info IC50 = 0.052 nM [1]
3 D0K2LB Drug Info IC50 = 0.23 nM [1]
4 D0S2LV Drug Info IC50 = 0.61 nM [1]
5 D0AF7J Drug Info IC50 = 0.66 nM [1]
6 D00VSX Drug Info IC50 = 0.67 nM [1]
7 D06EIP Drug Info IC50 = 0.68 nM [1]
8 D0J3JY Drug Info IC50 = 1 nM [1]
9 D02FRR Drug Info IC50 = 1.5 nM [1]
10 D0B2YJ Drug Info IC50 = 1.6 nM [1]
11 D07GZU Drug Info IC50 = 1.9 nM [1]
12 D0HR6P Drug Info IC50 = 2.1 nM [1]
13 D08YYW Drug Info IC50 = 2.3 nM [1]
14 D0GY4F Drug Info IC50 = 2.8 nM [1]
15 D00YBT Drug Info IC50 = 3.4 nM [1]
16 D0Q1MN Drug Info IC50 = 4.4 nM [1]
17 D05UNM Drug Info IC50 = 5.4 nM [1]
18 D00KTI Drug Info IC50 = 8.1 nM [1]
19 D01PCI Drug Info IC50 = 38 nM [1]
20 D0DM9L Drug Info IC50 = 38 nM [1]
21 D06BFA Drug Info IC50 = 120 nM [1]
22 D0C2EW Drug Info IC50 = 190 nM [1]
Patent ID WO2012042042
Title Selective Lsd1 and Dual Lsd1/Mao-B Inhibitors for Modulating Diseases Associated with Alterations In Protein Conformation.
Abstract The invention relates to methods and compositions for the treatment or prevention of protein conformation disorders. In particular, the invention relates to an LSD1 inhibitor for use in treating or preventing a protein conformation disorder, such as, e.g., Huntington Disease.
Applicant(s) Oryzon Genomics, Sa
Representative Drug(s) D02WXS Drug Info IC50 < 200 nM Click to Show More [1]
2 D0E7SF Drug Info IC50 < 200 nM [1]
3 D06KBT Drug Info IC50 < 300 nM [1]
4 D0IO2A Drug Info IC50 = 600 nM [1]
5 D0AI6J Drug Info IC50 = 1000 to 3000 nM [1]
6 D0Q1EG Drug Info IC50 = 1000 to 5000 nM [1]
7 D0PM2S Drug Info IC50 > 40000 nM [1]
8 D06VMN Drug Info N.A. [1]
Patent ID WO2014079964
Title Frozen Confection.
Abstract A frozen confection comprising from 0.002 wt% to 1 wt% of one or more compounds selected from the group consisting of benzyl cinnamate, piperonal, 4-methoxybenzaldehyde, and 4-hydroxybenzaldehyde is provided. A product for use in improving mood is also provided.
Applicant(s) Unilever Plc Unilever Nv Conopco, Inc., D / B / A Unilever
Representative Drug(s) D00BRD Drug Info N.A. Click to Show More [1]
2 D00NDF Drug Info N.A. [1]
3 D03SLR Drug Info N.A. [1]
4 D03VOJ Drug Info N.A. [1]
5 D03ZOH Drug Info N.A. [1]
6 D09SWE Drug Info N.A. [1]
7 D0B5YS Drug Info N.A. [1]
8 D0BT3Y Drug Info N.A. [1]
9 D0ME4N Drug Info N.A. [1]
10 D0N3SU Drug Info N.A. [1]
11 D0N9JJ Drug Info N.A. [1]
12 D0NH9P Drug Info N.A. [1]
13 D0O4QB Drug Info N.A. [1]
14 D0TR7N Drug Info N.A. [1]
Patent ID WO2011106105
Title Inhibitors for Antiviral Use.
Abstract The present invention relates to the use of potent selective LSD1 inhibitors and LSD1/MAO-B inhibitors for treating or preventing viral infections. Furthermore, the present invention relates to the new use of cyclopropylamine acetamide derivatives or cyclopropylamine derivatives, as defined herein, for treating or preventing viral infection and treating or preventing reactivation of a virus after latency.
Applicant(s) Oryzon Genomics, Sa
United States Patent and Trademark Office (USPTO)
Patent ID US20140186280
Title Neuroprotective and Neurorestorative Iron Chelators and Monoamine Oxidase Inhibitors and Uses Thereof.
Applicant(s) Varinel, Inc
Patent ID US20140315944
Title Substituted Naphthyridine and Quinoline Compounds As Mao Inhibitors.
Applicant(s) Dart Neuroscience, Llc
Patent ID US20100324147
Title Trans-2-Arylcyclopropylamine Derivatives As Inhibitors of Lysine-Specific Demethylase 1, Monoamine Oxidase A and B, and Their Preparation and Use for The Treatment of Cancer.
Applicant(s) Duke University, Usa
China National Intellectual Property Administration (CNIPA)
Patent ID CN105017195
Title 4-Hydroxycoumarin-3-Schiff Base Derivate and Use Thereof for Curing AlzheimerS Disease.
Applicant(s) University China Pharma
Representative Drug(s) D05RJG Drug Info IC50 = 711 nM Click to Show More [3]
2 D0DW5P Drug Info IC50 = 851 nM [3]
Patent ID CN104892556
Title Stilbene Coumarin Derivative As Well As Preparation Method and Application Thereof.
Applicant(s) University Hefei Technology
Representative Drug(s) D0L9FL Drug Info IC50 = 2780 nM [3]
Patent ID CN105153195
Title Tricyclo-Pyrazole [1,5-D] [1,4] Benzo Oxazepine-One Derivatives and Preparation Method and Application Thereof.
Representative Drug(s) D07UZL Drug Info IC50 = 1210 nM Click to Show More [3]
2 D04OXC Drug Info IC50 = 1890 nM [3]
Patent ID CN106588847
Title Dihydrocoumarin Derivatives As Well As Preparation Method and Application Thereof.
Applicant(s) SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Patent ID CN105601563
Title 6-Chloro-N-(4-(6-Chloro-Nicotinamide)Benzyl) Nicotinamide, and Preparation and Application Thereof.
Applicant(s) University Zhejiang Technology
Representative Drug(s) D0C7LB Drug Info IC50 = 44 nM [3]
Patent ID CN105534964
Title Application of Substituted Aryl Amides, or Nitrogen-Containing Heterocyclic Compounds In Manufacture of Monoamine Oxidase Inhibitor.
Applicant(s) University Zhejiang Technology
Representative Drug(s) D0J7HR Drug Info IC50 = 35880 nM [3]
Patent ID CN105503840
Title Tacrine-Coumarin Derivative Containing Triazole and Application of Derivative.
Applicant(s) University Guangdong Technology
Representative Drug(s) D0T9JB Drug Info IC50 = 180 nM [3]
Korean Intellectual Property Office (KIPO)
Patent ID KR20120089882
Title Composition Comprising The Extract of Loranthus Yadoriki Sieb. Having Monoamine Oxidase-Inhibiting Activity.
Applicant(s) Nat Arboretum Korea Forest Service
Intellectual Property Office of Australia (IP Australia)
Patent ID AU2014202864
Title Therapeutic Isoxazole Compounds.
Applicant(s) Helicon Therapeutics
References  Top
REF 1 Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
REF 2 LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.
REF 3 MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226.

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