Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Activated CDC42 kinase 1 (TNK2) | Patented-recorded | Target Info | ||
| UniProt ID | ACK1_HUMAN | ||||
| Gene Name | TNK2 | ||||
| Gene ID | 10188 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
| Proto-oncogene c-Src (SRC) | Target Info | PPI Info | [2] | ||
| Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [3] | ||
| RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [4] | ||
| Interacting Patented-recorded Target(s) | Activated CDC42 kinase 1 (ACK-1) | Target Info | PPI Info | [5] | |
| Interacting Literature-reported Target(s) | E3 ubiquitin-protein ligase NEDD4 (NEDD4) | Target Info | PPI Info | [1] | |
| Hsp90 co-chaperone Cdc37 (CDC37) | Target Info | PPI Info | [6] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol. 2010 Mar;30(6):1541-54. | ||||
| REF 2 | Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35. | ||||
| REF 3 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. | ||||
| REF 4 | Activated cdc42-associated kinase is up-regulated in non-small-cell lung cancer and necessary for FGFR-mediated AKT activation. Mol Carcinog. 2016 May;55(5):853-63. | ||||
| REF 5 | Regulation of Ack1 localization and activity by the amino-terminal SAM domain. BMC Biochem. 2010 Oct 27;11:42. | ||||
| REF 6 | HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3. Cell Signal. 2017 Nov;39:9-17. | ||||
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