Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T67619 Target Info
Target Name RAC-alpha serine/threonine-protein kinase (AKT1)
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; PKB alpha
Target Type Successful Target
Gene Name AKT1
Biochemical Class Kinase
UniProt ID
AKT1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [2]
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [4]
3 Co-localization [5]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Biochemical Activity [7]
3 Reconstituted Complex [8]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [10]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
Interacting Protein Name E3 SUMO-protein ligase PIAS2 (PIAS2) Interacting Protein Interacting Protein Info
UniProt ID
PIAS2_HUMAN 
Synonyms ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX.ALPHA; PIASX.BETA; SIZ2; ZMIZ4
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [5]
2 Yeast two hybrid [13]
Auxiliary transporters [+] 3 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [14]
3 Biochemical Activity [14]
4 Reconstituted Complex [14]
Interacting Protein Name Bcl2-associated agonist of cell death (BAD) Interacting Protein Interacting Protein Info
UniProt ID
BAD_HUMAN 
Synonyms BBC2; BCL2L8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [16]
3 Co-localization [5]
4 Reconstituted Complex [17]
Interacting Protein Name G protein subunit beta 1 (GNB1) Interacting Protein Interacting Protein Info
UniProt ID
GBB1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [18]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-purification [20]
3 Reconstituted Complex [20]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Ester hydrolases [+] 3 Ester hydrolases +
Interacting Target Name Serine/threonine PP1-alpha (PPP1CA) Successful Target Interacting Protein Info
UniProt ID
PP1A_HUMAN 
Synonyms Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase 1alpha; PPP1A; PP-1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Biochemical Activity [24]
Interacting Target Name Serine/threonine PP2A-alpha (PPP2CA) Clinical trial Target Interacting Protein Info
UniProt ID
PP2AA_HUMAN 
Synonyms Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; RP-C; Replication protein C; PP2A-alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Reconstituted Complex [25]
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Fluorescence Resonance Energy Transfer [27]
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [28]
3 Co-localization [29]
4 Reconstituted Complex [22]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
3 Reconstituted Complex [30]
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 5 (FKBP5) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP5_HUMAN 
Synonyms PPIase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP-51; FKBP51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [32]
2 Affinity Capture-Western [32]
Kinases [+] 20 Kinases +
Interacting Target Name MST-1 protein kinase (STK4) Literature-reported Target Interacting Protein Info
UniProt ID
STK4_HUMAN 
Synonyms STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4; MST1/N; MST1/C; MST-1; MST1; Mammalian STE20-like protein kinase 1; KRS2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [33]
2 Affinity Capture-Western [34]
3 Biochemical Activity [34]
4 Reconstituted Complex [33]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [35]
2 Protein-Fragment Complementation Assay [35]
3 Yeast two hybrid [36]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Biochemical Activity [37]
3 Co-localization [5]
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [38]
2 Protein-peptide [39]
3 Reconstituted Complex [40]
Interacting Target Name PI3-kinase alpha (PIK3CA) Successful Target Interacting Protein Info
UniProt ID
PK3CA_HUMAN 
Synonyms Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; PtdIns3kinase subunit p110alpha; PtdIns-3-kinase subunit alpha; PtdIns3kinase subunit alpha; PI3-kinase subunit alpha; PI3kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; p110alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [41]
3 Protein-Fragment Complementation Assay [42]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Biochemical Activity [44]
3 Reconstituted Complex [45]
Interacting Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Interacting Protein Info
UniProt ID
MK14_HUMAN 
Synonyms SAPK2A; P38 Mitogen-activatedprotein kinase alpha; P38 mitogen activatedprotein kinase; MXI2; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [30]
3 Fluorescence Resonance Energy Transfer [27]
Interacting Target Name DNA-dependent protein kinase catalytic (PRKDC) Clinical trial Target Interacting Protein Info
UniProt ID
PRKDC_HUMAN 
Synonyms P460; HYRC1; HYRC; DNPK1; DNA-PKcs; DNA-PK catalytic subunit; DNA-PK; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Biochemical Activity [46]
3 Reconstituted Complex [47]
Interacting Target Name MAPK-activated protein kinase 2 (MAPKAPK2) Clinical trial Target Interacting Protein Info
UniProt ID
MAPK2_HUMAN 
Synonyms MK-2; MK2; MAPKAP-K2; MAPKAPK-2; MAPKAP kinase 2; MAPKactivated protein kinase 2; MAP kinase-activated protein kinase 2; MAP kinaseactivated protein kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Co-localization [5]
3 Reconstituted Complex [30]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Biochemical Activity [48]
3 Co-localization [5]
Interacting Target Name Telomerase reverse transcriptase (TERT) Clinical trial Target Interacting Protein Info
UniProt ID
TERT_HUMAN 
Synonyms TRT; TP2; Telomerase-associated protein 2; Telomerase catalytic subunit; TCS1; HEST2; EST2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Fluorescence Resonance Energy Transfer [27]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Co-localization [5]
Interacting Target Name Phosphoinositide dependent protein kinase-1 (PDPK1) Clinical trial Target Interacting Protein Info
UniProt ID
PDPK1_HUMAN 
Synonyms PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Biochemical Activity [52]
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Biochemical Activity [54]
Interacting Target Name Protein kinase C zeta (PRKCZ) Patented-recorded Target Interacting Protein Info
UniProt ID
KPCZ_HUMAN 
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Biochemical Activity [56]
Interacting Target Name Activated CDC42 kinase 1 (ACK-1) Patented-recorded Target Interacting Protein Info
UniProt ID
ACK1_HUMAN 
Synonyms Tyrosine kinase non-receptor protein 2; Tyrosine kinase nonreceptor protein 2; ACK-1; ACK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Reconstituted Complex [58]
Interacting Target Name Integrin-linked protein kinase 1 (ILK) Patented-recorded Target Interacting Protein Info
UniProt ID
ILK_HUMAN 
Synonyms P59ILK; Integrin-linked protein kinase; Integrin-linked kinase; ILK-2; ILK2; ILK-1; ILK1; Beta-integrin-linked kinase; 59 kDa serine/threonine-protein kinase; 59 kDa serine/threonine protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Biochemical Activity [59]
Interacting Target Name Tyrosine-protein kinase CSK (CSK) Patented-recorded Target Interacting Protein Info
UniProt ID
CSK_HUMAN 
Synonyms Protein-tyrosine kinase CYL; C-Src kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Co-fractionation [61]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) Interacting Protein Interacting Protein Info
UniProt ID
MP2K4_HUMAN 
Synonyms JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK.1; SAPKK1; SEK1; SERK1; SKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Biochemical Activity [62]
Interacting Protein Name Serine/threonine-protein kinase 3 (STK3) Interacting Protein Interacting Protein Info
UniProt ID
STK3_HUMAN 
Synonyms KRS1; MST2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Biochemical Activity [64]
Lyases [+] 1 Lyases +
Interacting Protein Name Gamma-enolase (ENO2) Interacting Protein Interacting Protein Info
UniProt ID
ENOG_HUMAN 
Synonyms HEL.S.279; NSE
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Yeast two hybrid [65]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Reconstituted Complex [66]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Nitric-oxide synthase endothelial (NOS3) Clinical trial Target Interacting Protein Info
UniProt ID
NOS3_HUMAN 
Synonyms NOSIII; NOS,type III; NOS type III; Nitric oxide synthase, endothelial; ENOS; Endothelial NOS; Endothelial nitric oxide synthase; EC-NOS; Constitutive NOS; CNOS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [67]
2 Biochemical Activity [68]
3 Co-localization [5]
Peptidases [+] 1 Peptidases +
Interacting Target Name Ubiquitin thioesterase L1 (UCHL1) Preclinical Target Interacting Protein Info
UniProt ID
UCHL1_HUMAN 
Synonyms UCH-L1; Ubiquitin thiolesterase L1; Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Yeast two hybrid [65]
Transcription regulators [+] 5 Transcription regulators +
Interacting Protein Name Nuclease-sensitive element-binding protein 1 (YBX1) Interacting Protein Interacting Protein Info
UniProt ID
YBOX1_HUMAN 
Synonyms BP.8; CSDA2; CSDB; DBPB; MDR.NF1; NSEP.1; NSEP1; YB.1; YB1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [69]
2 Biochemical Activity [69]
3 Co-localization [69]
4 Reconstituted Complex [69]
Interacting Protein Name Max dimerization protein 1 (MXD1) Interacting Protein Interacting Protein Info
UniProt ID
MAD1_HUMAN 
Synonyms BHLHC58; MAD; MAD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Biochemical Activity [70]
3 Reconstituted Complex [70]
Interacting Target Name Notch-1 receptor (NOTCH1) Clinical trial Target Interacting Protein Info
UniProt ID
NOTC1_HUMAN 
Synonyms Translocation-associated notch protein TAN-1; Translocationassociated notch protein TAN1; TAN1; Notch 1 intracellular domain; Notch 1; NICD; Neurogenic locus notch homolog protein 1; hN1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [71]
2 Yeast two hybrid [72]
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [73]
2 Co-localization [5]
Interacting Protein Name Forkhead box protein O3 (FOXO3) Interacting Protein Interacting Protein Info
UniProt ID
FOXO3_HUMAN 
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [7]
2 Co-localization [5]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [74]
2 Biochemical Activity [75]
3 Co-localization [5]
Other proteins [+] 12 Other proteins +
Interacting Target Name Target of rapamycin complex 2 MAPKAP1 (MTORC2) Clinical trial Target Interacting Protein Info
UniProt ID
SIN1_HUMAN 
Synonyms TORC2 subunit MAPKAP1; Target of rapamycin complex 2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1; SIN1; SAPK-interacting protein 1; mSIN1; Mitogen-activated protein kinase 2-associated protein 1; MIP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [76]
2 Biochemical Activity [77]
3 Reconstituted Complex [78]
4 Yeast two hybrid [78]
Interacting Target Name MTOR complex 2 (RICTOR) Literature-reported Target Interacting Protein Info
UniProt ID
RICTR_HUMAN 
Synonyms Rapamycin-insensitive companion of mTOR; KIAA1999; hAVO3; AVO3 homolog
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [79]
2 Biochemical Activity [80]
3 Co-localization [5]
4 Reconstituted Complex [81]
Interacting Protein Name Akt phosphorylation enhancer (CCDC88A) Interacting Protein Interacting Protein Info
UniProt ID
GRDN_HUMAN 
Synonyms APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [82]
2 Biochemical Activity [83]
3 Reconstituted Complex [82]
4 Yeast two hybrid [83]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [84]
2 Co-localization [5]
3 Reconstituted Complex [84]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [85]
2 Biochemical Activity [86]
3 Co-localization [5]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [87]
2 Biochemical Activity [88]
3 Reconstituted Complex [87]
Interacting Protein Name Neurofibromin-2 (NF2) Interacting Protein Interacting Protein Info
UniProt ID
MERL_HUMAN 
Synonyms ACN; BANF; SCH
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Biochemical Activity [90]
3 Reconstituted Complex [89]
Interacting Target Name JNK-interacting protein 1 peptide (pepJIP1) Patented-recorded Target Interacting Protein Info
UniProt ID
JIP1_HUMAN 
Synonyms PRKM8IP; Mitogen-activated protein kinase 8-interacting protein 1; JNK-interacting protein 1; JNK MAP kinase scaffold protein 1; JIP-1; JIP1; Islet-brain 1; IB-1; IB1; C-Jun-amino-terminal kinase-interacting protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [91]
2 Biochemical Activity [92]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Reconstituted Complex [25]
Interacting Target Name T-cell leukemia/lymphoma protein 1A (TCL1A) Literature-reported Target Interacting Protein Info
UniProt ID
TCL1A_HUMAN 
Synonyms TCL-1 protein; TCL1 oncogene; TCL1; T-cell leukemia/lymphoma 1 oncogene; Protein p14 TCL1; P14 TCL1 protein; Oncogene TCL-1; Oncogene TCL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [93]
2 Yeast two hybrid [72]
Interacting Protein Name Disabled homolog 2-interacting protein (DAB2IP) Interacting Protein Interacting Protein Info
UniProt ID
DAB2P_HUMAN 
Synonyms AF9Q34; AIP.1; AIP1; DIP1/2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [94]
2 Biochemical Activity [95]
Interacting Protein Name Periplakin (PPL) Interacting Protein Interacting Protein Info
UniProt ID
PEPL_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [96]
2 Yeast two hybrid [97]
References  Top
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REF 73 Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11278-83.
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REF 89 Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol. 2007 Oct;9(10):1199-207.
REF 90 Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin. Neoplasia. 2011 Jul;13(7):643-52.
REF 91 Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 2002 Aug 15;35(4):697-709.
REF 92 Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH. FEBS Lett. 2006 Jan 9;580(1):9-14.
REF 93 The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407.
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REF 96 Binding of protein kinase B to the plakin family member periplakin. J Cell Sci. 2002 Oct 15;115(Pt 20):3957-66.
REF 97 Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 2008 Sep;7(9):3879-89.

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